在胶质母细胞瘤治疗中的作用。
Role of Resection in Glioblastoma Management.
机构信息
Department of Neurological Surgery, Northwestern University, Northwestern Medicine, 676 North Saint Clair Street, Suite 2210, Chicago, IL 60611, USA.
Department of Neurological Surgery, Northwestern University, Northwestern Medicine, 676 North Saint Clair Street, Suite 2210, Chicago, IL 60611, USA; Department of Neurology, Northwestern University, 676 North Saint Clair Street, Suite 2210, Chicago, IL 60611, USA; Department of Medicine, Division of Hematology and Oncology, Northwestern University, 676 North Saint Clair Street, Suite 2210, Chicago, IL 60611, USA; Lou and Jean Malnati Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 North Saint Clair Street, Suite 2210, Chicago, IL 60611, USA.
出版信息
Neurosurg Clin N Am. 2021 Jan;32(1):9-22. doi: 10.1016/j.nec.2020.08.002. Epub 2020 Nov 5.
Whenever possible, maximal safe resection is the first intervention for management of glioblastoma. Resection offers tissue for diagnosis, decompression of the brain, cytoreduction, and has been associated with prolonged survival in numerous retrospective studies. In this review, we provide a critical overview of the literature associating glioblastoma resection with survival. We discuss techniques that enhance extent of resection, and the role of clinical and surgeon-variables. At last, we analyze the covariates and confounders that might influence the relationship between extent of resection and survival for glioblastoma, as these might ultimately also influence outcomes and other therapeutic interventions tested in trials.
在可能的情况下，最大限度地安全切除是胶质母细胞瘤治疗的首要干预措施。切除可提供组织用于诊断、脑减压、细胞减灭，并在许多回顾性研究中与延长生存时间相关。在这篇综述中，我们对与胶质母细胞瘤切除与生存相关的文献进行了批判性的综述。我们讨论了增强切除范围的技术，以及临床和外科医生变量的作用。最后，我们分析了可能影响胶质母细胞瘤切除范围与生存之间关系的协变量和混杂因素，因为这些因素最终也可能影响试验中测试的其他治疗干预措施的结果。
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