中国初中女生家长对 HPV 疫苗接种的偏好：一项离散选择实验。
Parental preferences for HPV vaccination in junior middle school girls in China: A discrete choice experiment.
机构信息
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, China; Center for Drug Safety and Policy Research, Xi'an Jiaotong University, China; Shaanxi Center for Health Reform and Development Research, Xi'an Jiaotong University, China; Research Institute for Drug Safety and Monitoring, Institute of Pharmaceutical Science and Technology, China's Western Technological Innovation Harbor, Xi'an, China.
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, China; Center for Drug Safety and Policy Research, Xi'an Jiaotong University, China; Shaanxi Center for Health Reform and Development Research, Xi'an Jiaotong University, China; Research Institute for Drug Safety and Monitoring, Institute of Pharmaceutical Science and Technology, China's Western Technological Innovation Harbor, Xi'an, China.
出版信息
Vaccine. 2020 Dec 14;38(52):8310-8317. doi: 10.1016/j.vaccine.2020.11.020. Epub 2020 Nov 20.
BACKGROUND
Cervical cancer is the second most common cancer in Chinese women. Human papillomavirus (HPV) vaccines have not yet been introduced in the Chinese national immunization program, and people vaccinate voluntarily at their own expense. Therefore, it is important to study the factors that could impact parents' decisions for HPV vaccination.
OBJECTIVE
To quantify parental preferences regarding HPV vaccination for junior middle school-aged girls.
METHOD
A discrete choice experiment (DCE) survey was conducted to assess parents' preferences for HPV vaccines. Data were collected from parents of girls aged 12-16 years in 11 middle schools of Shandong Province. We evaluated preferences for five attributes of HPV vaccination (vaccine effectiveness, protection duration, risk of side effects, cost, and vaccination location). Conditional logit regressions were adopted for analyses.
RESULTS
995 parents completed valid DCE questions. All attributes influenced parents' willingness to vaccinate. Comparatively highly educated parents preferred more on higher vaccine effectiveness and lower side effects risks while more intended to accept higher prices. Parents were willing to trade 2326.32 CNY for an increase in HPV vaccine effectiveness from 50% to 90%. Nearly 70% percent of the respondents were predicted to prefer multiple improvements in HPV vaccination (protection increased from 70% to 95%, duration increased from 9 years to 15 years, and vaccination location changed from vaccination center to school) to the base case.
CONCLUSION
Various vaccine characteristics and implementation strategies influence respondents' preferences. Health education with evidence-based information about HPV vaccines would help parents make informed decisions. The findings can also assist agencies responsible for HPV vaccination implementation and cervical cancer prevention in China in decisions regarding vaccination financing and vaccine approval.
背景
宫颈癌是中国女性第二大常见癌症。人乳头瘤病毒（HPV）疫苗尚未纳入中国国家免疫规划，人们自愿自费接种。因此，研究可能影响父母 HPV 疫苗接种决策的因素非常重要。
目的
量化父母对初中女生 HPV 疫苗接种的偏好。
方法
采用离散选择实验（DCE）调查评估父母对 HPV 疫苗的偏好。数据来自山东省 11 所中学 12-16 岁女孩的家长。我们评估了 HPV 疫苗接种的五个属性（疫苗效力、保护持续时间、副作用风险、成本和接种地点）的偏好。采用条件逻辑回归进行分析。
结果
995 名家长完成了有效的 DCE 问题。所有属性都影响了父母接种疫苗的意愿。相对而言，受教育程度较高的父母更喜欢更高的疫苗效力和更低的副作用风险，而更多的父母愿意接受更高的价格。父母愿意为 HPV 疫苗效力从 50%提高到 90%而支付 2326.32 元人民币。近 70%的受访者预测更愿意选择多种 HPV 疫苗接种的改进（保护效力从 70%提高到 95%，保护持续时间从 9 年延长到 15 年，接种地点从接种中心改为学校）而不是基础方案。
结论
各种疫苗特征和实施策略影响了受访者的偏好。提供基于证据的 HPV 疫苗相关知识的健康教育将有助于家长做出知情决策。研究结果也可为中国负责 HPV 疫苗接种实施和宫颈癌预防的机构在疫苗融资和疫苗批准方面的决策提供参考。
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