采用 I-125 放射性敷贴治疗后伴或不伴放射性视网膜病变的葡萄膜黑色素瘤治疗眼以及未受照射的对侧眼的自动定量 OCTA 测量。
Automated quantitative OCTA measurements of uveal melanoma-treated eyes with and without radiation retinopathy after I-125 plaque therapy and of nonirradiated fellow eyes.
机构信息
Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL, 60612, USA.
出版信息
Eye (Lond). 2021 Mar;35(3):769-776. doi: 10.1038/s41433-020-01237-8. Epub 2020 Nov 23.
OBJECTIVES
To determine if commercial OCTA measurements can provide quantitative biomarkers for detection of radiation retinopathy (RR) s/p I-125 plaque brachytherapy in patients with uveal melanoma.
METHODS
Retrospective review of 6 × 6 mm OCTA images of nonirradiated fellow eyes (group 1, 28 eyes), eyes without RR (group 2, 22 eyes), eyes with RR (group 3, 13 eyes). We used automated AngioVue AngioAnalytics OCTA software determinations of FAZ size, perimeter size, and 27 capillary density measurements (nine regions of each segmentation: full-thickness retina, superficial plexus, deep plexus).
RESULTS
Average time since irradiation was 1.9 years in group 2, and 3.7 years in group 3. FAZ size was 1.2 mm in group 3 compared with 0.2 mm in group 1 and 0.3 mm in group 2 (both p < 0.001). Capillary density was statistically significantly reduced in group 3 compared with group 1 in all 27 regions. Group 2 had significantly decreased superficial plexus capillary density compared with group 1 in three regions. Group 3 had significantly reduced capillary density compared with group 2 in 6/27 (22%) regions. Linear regression showed a change in whole-scan density of -1.5 per year after irradiation in the full-thickness retina segmentation (p = 0.008).
CONCLUSION
Quantitative OCTA may aid in early detection of RR.
目的
确定商用 OCTA 测量是否可以为放射性视网膜病变 (RR) 提供定量生物标志物，以检测眼黑色素瘤患者接受 I-125 放射性碘 125 贴剂近距离放射治疗后的情况。
方法
回顾性分析 6×6mm 未照射对侧眼（第 1 组，28 只眼）、无 RR 眼（第 2 组，22 只眼）和 RR 眼（第 3 组，13 只眼）的 OCTA 图像。我们使用自动 AngioVue AngioAnalytics OCTA 软件确定 FAZ 大小、周长大小和 27 个毛细血管密度测量值（每个分割的 9 个区域：全层视网膜、浅层丛、深层丛）。
结果
第 2 组的平均照射后时间为 1.9 年，第 3 组为 3.7 年。第 3 组的 FAZ 大小为 1.2mm，而第 1 组和第 2 组分别为 0.2mm 和 0.3mm（均 p<0.001）。与第 1 组相比，第 3 组的毛细血管密度在所有 27 个区域均显著降低。与第 1 组相比，第 2 组在三个区域的浅层丛毛细血管密度显著降低。与第 2 组相比，第 3 组在 6/27（22%）个区域的毛细血管密度显著降低。线性回归显示，在全层视网膜分割中，照射后全扫描密度每年减少 1.5（p=0.008）。
结论
定量 OCTA 可能有助于早期发现 RR。
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