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Imaging of Uveal Melanoma-Current Standard and Methods in Development.

作者信息

Solnik Małgorzata, Paduszyńska Natalia, Czarnecka Anna M, Synoradzki Kamil J, Yousef Yacoub A, Chorągiewicz Tomasz, Rejdak Robert, Toro Mario Damiano, Zweifel Sandrine, Dyndor Katarzyna, Fiedorowicz Michał

机构信息

Faculty of Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 5 Roentgen Str., 02-781 Warsaw, Poland.

出版信息

Cancers (Basel). 2022 Jun 27;14(13):3147. doi: 10.3390/cancers14133147.


DOI:10.3390/cancers14133147
PMID:35804919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9265106/
Abstract

Uveal melanoma is the most common primary intraocular malignancy in adults, characterized by an insidious onset and poor prognosis strongly associated with tumor size and the presence of distant metastases, most commonly in the liver. Contrary to most tumor identification, a biopsy followed by a pathological exam is used only in certain cases. Therefore, an early and noninvasive diagnosis is essential to enhance patients' chances for early treatment. We reviewed imaging modalities currently used in the diagnostics of uveal melanoma, including fundus imaging, ultrasonography (US), optical coherence tomography (OCT), single-photon emission computed tomography (SPECT), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), fundus autofluorescence (FAF), as well as positron emission tomography/computed tomography (PET/CT) or magnetic resonance imaging (MRI). The principle of imaging techniques is briefly explained, along with their role in the diagnostic process and a summary of their advantages and limitations. Further, the experimental data and the advancements in imaging modalities are explained. We describe UM imaging innovations, show their current usage and development, and explain the possibilities of utilizing such modalities to diagnose uveal melanoma in the future.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/06a916fc6f27/cancers-14-03147-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/d73f66daae0d/cancers-14-03147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/8e2fc2451fe7/cancers-14-03147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/5ad181d0c685/cancers-14-03147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/a1b6579be64d/cancers-14-03147-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/e7d8af8d2d5c/cancers-14-03147-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/1a02916f599f/cancers-14-03147-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/6d0b654dabec/cancers-14-03147-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/06a916fc6f27/cancers-14-03147-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/d73f66daae0d/cancers-14-03147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/8e2fc2451fe7/cancers-14-03147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/5ad181d0c685/cancers-14-03147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/a1b6579be64d/cancers-14-03147-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/e7d8af8d2d5c/cancers-14-03147-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/1a02916f599f/cancers-14-03147-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/6d0b654dabec/cancers-14-03147-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b96/9265106/06a916fc6f27/cancers-14-03147-g008.jpg

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引用本文的文献

[1]
Advances in Positron Emission Tomography/Computed Tomography for Diagnosing and Managing Primary Posterior Uveal Melanoma.

Med Sci Monit. 2025-8-19

[2]
Diagnostic value of F-FDG PET/CT in the follow-up of conjunctival melanoma.

Ann Nucl Med. 2025-8-15

[3]
Choroidal metastasis as the first sign of small cell lung cancer: A case report.

Oncol Lett. 2025-7-18

[4]
A nomogram to predict cancer-specific survival of ocular melanoma.

Discov Oncol. 2025-6-12

[5]
Current Treatment of Uveal Melanoma.

Cancers (Basel). 2025-4-23

[6]
Yield of Multimodal Imaging in Iris Amelanotic Lesions: A Masked Case-Control Study.

Diseases. 2025-3-28

[7]
Estimating uveal melanoma volume with ellipsoid tumour models.

Acta Ophthalmol. 2025-9

[8]
Evaluation of OPTOS wide-field fundus image projections for radiotherapy planning of uveal melanoma.

J Appl Clin Med Phys. 2025-4

[9]
Differentiating Choroidal Melanomas and Nevi Using a Self-Supervised Deep Learning Model Applied to Clinical Fundoscopy Images.

Ophthalmol Sci. 2024-11-8

[10]
Nodular Posterior Scleritis Mimicking Non-pigmented Choroidal Melanoma: A Case Report and Literature Review.

Cureus. 2024-11-6

本文引用的文献

[1]
New Perspectives for Eye-Sparing Treatment Strategies in Primary Uveal Melanoma.

Cancers (Basel). 2021-12-28

[2]
Prognostic Biomarkers in Uveal Melanoma: The Status Quo, Recent Advances and Future Directions.

Cancers (Basel). 2021-12-25

[3]
Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.

N Engl J Med. 2021-9-23

[4]
RETINAL MICROVASCULAR CHANGES IN UVEAL MELANOMA FOLLOWING CONBERCEPT INJECTION AFTER PLAQUE RADIOTHERAPY AS DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Retina. 2021-12-1

[5]
Can gray values be converted to Hounsfield units? A systematic review.

Dentomaxillofac Radiol. 2022-1-1

[6]
Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography.

Diagnostics (Basel). 2021-4-29

[7]
Current molecular and clinical insights into uveal melanoma (Review).

Int J Oncol. 2021-4

[8]
Application of Multimodal and Molecular Imaging Techniques in the Detection of Choroidal Melanomas.

Front Oncol. 2021-2-1

[9]
White matter: A good reference for the signal intensity evaluation in magnetic resonance imaging for the diagnosis of uveal melanoma.

Neuroradiol J. 2021-4

[10]
Automated quantitative OCTA measurements of uveal melanoma-treated eyes with and without radiation retinopathy after I-125 plaque therapy and of nonirradiated fellow eyes.

Eye (Lond). 2021-3

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