Calle C, Carranza M C, Simón M A, Torres A, Mayor P
Department of Biochemistry, School of Medicine, Complutese University, Madrid, Spain.
Biosci Rep. 1987 Sep;7(9):713-9. doi: 10.1007/BF01116864.
Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000 +/- 48,000 (3) receptors/cell and controls 189,000 +/- 30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25 x 10(-9) M and controls 0.57 x 10(-9) M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue.
来自慢性内源性皮质醇增多症（库欣综合征）患者的人类脂肪细胞在低未标记胰岛素浓度下胰岛素结合呈统计学显著下降，但受体数量无变化（库欣综合征患者为180,000 ± 48,000（3）个受体/细胞，对照组为189,000 ± 30,000（7）个受体/细胞），同时表观受体亲和力下降四倍（半数有效剂量：库欣综合征患者为2.25×10⁻⁹ M，对照组为0.57×10⁻⁹ M），且对胰岛素抗脂解作用的敏感性降低。这些情况可能代表了人类脂肪组织中高水平皮质醇对胰岛素受体进行慢性内源性调节的最终状态。
