Determination of split renal function by PSMA imaging: comparison of Ga-PSMA-11 PET with Tc-MAG3 scintigraphy.

MAG3 scintigraphy with determination of split renal function (SRF) is a standard procedure in patients with metastasized castration-resistant prostate carcinoma (mCRPC) undergoing PSMA radioligand therapy (PSMA-RLT). These patients also receive frequent PSMA PET/CT scans for staging and follow up. PSMA is not only overexpressed in prostate cancer epithelial cells, but also physiologically overexpressed in the proximal tubular cells of the kidney. This study investigates the utility of PSMA-targeted imaging for determination of relative renal function. mCRPC patients (n = 97) having received Ga-PSMA-11 PET/CT and Tc-MAG3 scintigraphy in close temporal relationship were included in this retrospective study. PSMA-PET-derived SRF was calculated according to the bilateral renal PSMA content (total kidney PSMA = SUVmean × volume), MAG3-based SRF (SRF) using the common standard integral method of the renal secretion phase. The agreement of SRF and SRF was statistically tested using Pearson correlation and Bland-Altman analysis. The correlation between both SRF assessment methods was highly significant (P < 0.001) with r=0.91. Bland-Altman analysis confirmed agreement of the measurements. High correlation and agreement were also observed in the subgroup analyses of patients with normal and reduced renal function (r=0.81, P < 0.001 and r=0.98, P < 0.001). Renal tubular PSMA expression allows assessment of split renal function by Ga-PSMA-11 PET/CT imaging. Additional MAG3 scintigraphy for the purpose of quantifying relative renal function contribution may be spared in settings where PSMA PET is performed; this insight could save time and unnecessary examinations.