Zhao Yu, Zhang Xianwen, Song Zhenhua, Wei Danian, Wang Hong, Chen Wei, Sun Guodong, Ma Weiying, Chen Kebing
Department of Hematology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Med (Lausanne). 2020 Nov 3;7:584728. doi: 10.3389/fmed.2020.584728. eCollection 2020.
Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is associated with significant progress in biological research and has attracted increasing attention. However, the impact of ATAC-seq on cancer biology has not been objectively analyzed. We categorized 440 ATAC-seq publications according to the publication date, type, field, and country. R 3.6.2 was used to analyze the distribution of research fields. VOSviewer was used for country co-authorship and author co-authorship analyses, and GraphPad Prism 8 was used for correlation analyses of the factors that may affect the number of articles published in different countries. We found that ATAC-seq plays roles in carcinogenesis, anticancer immunity, targeted therapy, and metastasis risk predictions and is most frequently used in studies of leukemia among all types of cancer. We found a significantly strong correlation between the top 10 countries in terms of the number of publications and the gross expenditure on research and development (R&D), the number of universities, and the number of researchers. At present, ATAC-seq technology is undergoing a period of rapid development, making it inseparable from the emphasis and investment in scientific research by many countries. Collectively, ATAC-seq has advantages in the study of the cancer mechanisms because it can detect nucleic acids and thus has good application prospects in the field of cancer, especially in leukemia studies. As a country's economic strength increases and the emphasis on scientific research deepens, ATAC-seq will definitely play a more significant role in the field of cancer biology.
利用测序技术进行转座酶可及染色质分析（ATAC-seq）在生物学研究中取得了显著进展，并引起了越来越多的关注。然而，ATAC-seq对癌症生物学的影响尚未得到客观分析。我们根据出版日期、类型、领域和国家对440篇ATAC-seq出版物进行了分类。使用R 3.6.2分析研究领域的分布。使用VOSviewer进行国家合作作者和作者合作作者分析，使用GraphPad Prism 8对可能影响不同国家发表文章数量的因素进行相关性分析。我们发现，ATAC-seq在致癌作用、抗癌免疫、靶向治疗和转移风险预测中发挥作用，并且在所有类型的癌症中最常用于白血病研究。我们发现，在出版物数量排名前十的国家与研发总支出、大学数量和研究人员数量之间存在显著的强相关性。目前，ATAC-seq技术正处于快速发展时期，这离不开许多国家对科研的重视和投入。总体而言，ATAC-seq在癌症机制研究中具有优势，因为它可以检测核酸，因此在癌症领域，尤其是白血病研究中具有良好的应用前景。随着一个国家经济实力的增强和对科研的重视程度的加深，ATAC-seq肯定会在癌症生物学领域发挥更重要的作用。
