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[辐射嵌合体中造血系统基本部分的动力学]

[Kinetics of the basic sections of the hemopoietic system in radiation chimeras].

作者信息

Kondratenko N F

出版信息

Biull Eksp Biol Med. 1977 Aug;84(8):227-9.

PMID:332250
Abstract

During first 3 days after mice irradiation and syngeneic bone marrow transplantation in them the number of CFUs (about 0,5% of the injected cells) was stable, although the proliferation induction began 24 hours after transplantation. As it was shown by the method of "thymidine self-distruction". Twenty four hours later all the CFUs entered the mitotic cycle. On the contrary, the commited cells (granulopoesis precursors) compartment (CFUc) enters the logarithmic growth phase since the first day. The exponential growth of the CFUs number was observed from the 4th day simultaneously with the increasing of the proliferation rate of CFUc and the beginning of the recovery of the bone marrow cells total number. In late radiation chimeras (1 month after radiation and reconstitution) the total number of CFUs was 50--70% of the initial. The other hemopoetic parameters were in the normal limits.

摘要

在小鼠接受照射并进行同基因骨髓移植后的头3天,集落形成单位(CFUs)的数量(约为注入细胞的0.5%)保持稳定,尽管增殖诱导在移植后24小时就已开始。通过“胸腺嘧啶核苷自我破坏”方法显示,24小时后所有CFUs进入有丝分裂周期。相反,定向细胞(粒细胞生成前体细胞)区室(CFUc)从第一天起就进入对数生长期。从第4天开始观察到CFUs数量呈指数增长,同时CFUc的增殖率增加,骨髓细胞总数开始恢复。在晚期辐射嵌合体(辐射和重建后1个月)中,CFUs的总数为初始数量的50 - 70%。其他造血参数在正常范围内。

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