意大利新冠疫情相关死亡病例中痴呆症的患病率及临床关联因素
Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy.
作者信息
Canevelli Marco, Palmieri Luigi, Raparelli Valeria, Lo Noce Cinzia, Colaizzo Elisa, Tiple Dorina, Vaianella Luana, Vanacore Nicola, Brusaferro Silvio, Onder Graziano
机构信息
National Center for Disease Prevention and Health Promotion Istituto Superiore di Sanità Rome Italy.
Department of Human Neuroscience Sapienza University of Rome Rome Italy.
出版信息
Alzheimers Dement (Amst). 2020 Nov 14;12(1):e12114. doi: 10.1002/dad2.12114. eCollection 2020.
INTRODUCTION
We aimed at exploring the proportion of patients dying with COVID-19 and concomitant dementia in Italy, as well as their clinical characteristics and trajectories of care.
METHODS
The proportion of COVID-19-related deaths occurring in people with dementia and the clinical characteristics of deceased individuals according to their dementia status were explored by considering the medical charts of a representative sample of patients deceased in Italian hospitals (n = 2621).
RESULTS
A total of 415 individuals with dementia were identified in the study population, accounting for 15.8% of overall COVID-19-related deaths. Patients with dementia less frequently presented with cough, had lower chance of receiving supportive therapies and intensive care approaches, and showed a faster clinical worsening as compared with individuals with intact cognition.
DISCUSSION
Dementia confers a relevant risk of adverse outcomes in case of SARS-CoV-2 infection and influences the clinical presentation, course and management of affected individuals.
引言
我们旨在探究意大利死于新冠病毒病（COVID-19）且伴有痴呆症的患者比例，以及他们的临床特征和护理轨迹。
方法
通过查阅意大利医院死亡患者代表性样本（n = 2621）的病历，探讨痴呆症患者中与COVID-19相关的死亡比例以及根据痴呆症状态划分的死者临床特征。
结果
在研究人群中总共识别出415名痴呆症患者，占COVID-19相关死亡总数的15.8%。与认知功能正常的个体相比，痴呆症患者咳嗽症状较少见，接受支持性治疗和重症监护的机会较低，且临床恶化更快。
讨论
痴呆症会增加感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）时出现不良结局的风险，并影响受影响个体的临床表现、病程和治疗。
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