Mountford C E, Tattersall M H
Ludwig Institute for Cancer Research (Sydney Branch), NSW, Australia.
Cancer Surv. 1987;6(2):285-314.
High resolution proton magnetic resonance spectroscopy is a powerful technology in the study of tumour cell membranes. Lipid domains in the plasma membrane are the origin of high resolution spectra seen in tumour cells, and changes in those domains can be correlated not only with changes in lipid and carbohydrate components of the membrane, but also with changed tumour behaviour, ie metastatic capacity, and sensitivity to cytotoxic drug treatment. An understanding of the biological importance of lipid changes in the cell membrane paves the way to high resolution spectroscopy being useful in classifying tumours, and perhaps in tumour imaging.
高分辨率质子磁共振波谱是肿瘤细胞膜研究中的一项强大技术。质膜中的脂类区域是肿瘤细胞中高分辨率谱的起源，这些区域的变化不仅可以与膜中脂质和碳水化合物成分的变化相关，还可以与肿瘤行为的改变，即转移能力和对细胞毒性药物治疗的敏感性相关。了解细胞膜中脂质变化的生物学重要性为高分辨率波谱在肿瘤分类甚至肿瘤成像中的应用铺平了道路。
