Autism Clinic for Translational Research, Brain and Mind Centre, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Pharmacology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Autism Res. 2021 Jan;14(1):75-85. doi: 10.1002/aur.2437. Epub 2020 Nov 22.
Decreased heart rate variability (HRV) is considered a common marker of autonomic dysfunction that contributes to poor health outcomes. While some studies have suggested that children with autism spectrum disorder (ASD) show reduced HRV, research is yet to consider whether this may be associated with medication use and symptom severity. This study examined the relationship between resting state HRV, medication use and symptom severity in children diagnosed with ASD. Children with ASD (N = 86), aged between 3 and 12 years (M = 8.09), were compared to 44 neurotypical children of similar age (M = 7.15). Laboratory assessment of HRV involved 5 min of non-invasive baseline electrocardiogram assessments while participants viewed an age-appropriate non-verbal animated video. Time-domain and frequency-domain HRV measures were analyzed. ASD symptom severity was assessed using the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and Social Responsiveness Scale (SRS-2). Results indicated that children with ASD exhibited reduced resting HRV relative to neurotypical children. Subsequent analyses within the ASD group suggested that this group difference was greater in children who were taking psychotropic medication (N = 36). Our data also provides tentative evidence of a relationship between HRV and social impairment symptoms in children with ASD, with more severe repetitive behaviors (as measured by the ADOS-2) associated with decreased resting HRV. Overall, these findings suggest that HRV may be atypical in children with ASD and suggest the importance of exploring HRV as a risk factor for cardiovascular health in this group. LAY SUMMARY: Cardiac activity, such as heart rate variability (HRV), can provide insight into the autonomic nervous system. This study reports on the association between resting-state HRV and autonomic nervous system activity in young children with autism spectrum disorder (ASD) compared to neurotypical children. These results may help us understand what underlies autonomic nervous system dysfunction and the potential pathophysiological mechanisms leading to increased cardiovascular risk in ASD.
心率变异性（HRV）降低被认为是自主神经功能障碍的常见标志物，可导致健康状况不佳。虽然一些研究表明，自闭症谱系障碍（ASD）儿童的 HRV 降低，但研究尚未考虑这是否与药物使用和症状严重程度有关。本研究探讨了诊断为 ASD 的儿童静息状态 HRV、药物使用和症状严重程度之间的关系。将 86 名年龄在 3 至 12 岁之间（M = 8.09 岁）的 ASD 儿童与 44 名年龄相似的神经典型儿童（M = 7.15 岁）进行比较。HRV 的实验室评估包括 5 分钟的非侵入性基线心电图评估，同时参与者观看适合年龄的非言语动画视频。分析了时域和频域 HRV 指标。使用自闭症诊断观察量表第二版（ADOS-2）和社会反应量表（SRS-2）评估 ASD 症状严重程度。结果表明，与神经典型儿童相比，ASD 儿童的静息 HRV 降低。ASD 组内的后续分析表明，服用精神药物（N = 36）的儿童组间差异更大。我们的数据还提供了 ASD 儿童 HRV 与社会功能障碍症状之间关系的初步证据，ADOS-2 测量的更严重的重复行为与静息 HRV 降低有关。总体而言，这些发现表明 ASD 儿童的 HRV 可能异常，并表明探索 HRV 作为该人群心血管健康风险因素的重要性。
解析：这段英文文本是关于医学研究的学术论文，需要将专业的医学词汇和术语准确地翻译出来。
