口腔念珠菌病患者唾液中抗白色念珠菌抗体的免疫球蛋白A1和A2亚类
Immunoglobulin A1 and A2 subclass of salivary antibodies to Candida albicans in patients with oral candidosis.
作者信息
Jeganathan S, Ufomata D, Hobkirk J A, Ivanyi L
机构信息
Department of Clinical Pathology and Immunology, Institute of Dental Surgery, Eastman Dental Hospital, London, UK.
出版信息
Clin Exp Immunol. 1987 Nov;70(2):316-21.
Abstract
Immunoglobulin A antibody titres to a cytoplasmic protein extract of Candida albicans were determined by ELISA in saliva from 20 patients with oral candidosis and 21 controls. Patients had significantly increased levels of salivary IgA anti-Candida antibodies when compared with controls (P less than 0.001). Antibody levels were associated with IgA1 subclass in 90% of the patients; in contrast, IgA2 subclass was predominant in 67% of the controls. Antifungal therapy resulted in significantly decreased IgA1 titres (P less than 0.05) whilst the mean IgA2 antibody titre remained unchanged. The results indicate that Candida infection may change the subclass pattern of salivary IgA antibodies.
摘要
采用酶联免疫吸附测定法（ELISA）测定了20例口腔念珠菌病患者和21名对照者唾液中针对白色念珠菌胞质蛋白提取物的免疫球蛋白A抗体滴度。与对照组相比，患者唾液中抗念珠菌IgA抗体水平显著升高（P<0.001）。90%的患者抗体水平与IgA1亚类相关；相比之下，67%的对照者中IgA2亚类占主导。抗真菌治疗使IgA1滴度显著降低（P<0.05），而IgA2抗体平均滴度保持不变。结果表明，念珠菌感染可能会改变唾液IgA抗体的亚类模式。
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