Epstein J B, Kimura L H, Menard T W, Truelove E L, Pearsall N N
Arch Oral Biol. 1982;27(6):469-74. doi: 10.1016/0003-9969(82)90086-3.
Host-parasite interactions were studied in four groups: non-infected controls; infected carriers of Candida albicans without evidence of candidiasis; subjects with acute candidiasis; and subjects with chronic candidiasis. Specific anti-candida antibodies were demonstrated in saliva from subjects of all four groups; the titres reflected the degree of antigenic stimulation, being significantly higher in candidiasis than in controls or infected carriers. The adherence of C. albicans to buccal epithelial cells was not significantly different in a given saliva, regardless of whether the assay was carried out with autologous C. albicans and epithelial cells or with a stock strain in a standardized assay. Therefore, the standard assay was used to study the effects of specific salivary antibodies on adherence. A significant inverse correlation was found between salivary IgA anti-candida antibodies and the adherence of C. albicans to buccal epithelial cells, suggesting that IgA antibodies can inhibit adherence of candida to the oral mucosa. In some instances, removal of antibodies led to a significant increase in adherence; however, often this was not the case, indicating that some but not all of the antibodies present were capable of inhibiting the adherence of C. albicans to epithelial cells.
未感染的对照组；白色念珠菌感染携带者但无念珠菌病证据；急性念珠菌病患者；以及慢性念珠菌病患者。在所有四组受试者的唾液中均检测到特异性抗念珠菌抗体；抗体滴度反映了抗原刺激程度，念珠菌病患者的滴度显著高于对照组或感染携带者。在给定的唾液中，白色念珠菌对颊上皮细胞的黏附在使用自体白色念珠菌和上皮细胞进行检测时，与使用标准检测中的标准菌株进行检测时相比，并无显著差异。因此，采用标准检测来研究特异性唾液抗体对黏附的影响。发现唾液中抗念珠菌IgA抗体与白色念珠菌对颊上皮细胞的黏附之间存在显著的负相关，这表明IgA抗体可抑制念珠菌对口腔黏膜的黏附。在某些情况下，去除抗体导致黏附显著增加；然而，情况往往并非如此，这表明存在的部分而非全部抗体能够抑制白色念珠菌对上皮细胞的黏附。
