Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Elife. 2020 Nov 23;9:e61469. doi: 10.7554/eLife.61469.
Sense of coherence (SoC) is the origin of health according to Antonovsky. The link between SoC and risk of cancer has however rarely been assessed. We performed a cohort study of 46,436 women from the Karolinska Mammography Project for Risk Prediction of Breast Cancer (Karma). Participants answered a SoC-13 questionnaire at recruitment to Karma and were subsequently followed up for incident breast cancer. Multivariate Cox models were used to assess the hazard ratios (HRs) of breast cancer in relation to SoC. We identified 771 incident cases of breast cancer during follow-up (median time: 5.2 years). No association was found between SoC, either as a categorical (strong vs. weak SoC, HR: 1.08, 95% CI: 0.90-1.29) or continuous (HR: 1.08; 95% CI: 1.00-1.17 per standard deviation increase of SoC) variable, and risk of breast cancer. In summary, we found little evidence to support an association between SoC and risk of breast cancer.
根据 Antonovsky 的观点，社会感（SoC）是健康的起源。然而，SoC 与癌症风险之间的联系很少被评估。我们对来自 Karolinska 乳腺癌风险预测的乳腺摄影项目（Karma）的 46436 名女性进行了队列研究。参与者在参加 Karma 时回答了一个 SoC-13 问卷，随后对乳腺癌的发病进行了随访。使用多变量 Cox 模型评估 SoC 与乳腺癌发病风险的危害比（HRs）。在随访期间（中位时间：5.2 年），我们确定了 771 例乳腺癌新发病例。SoC 无论是作为分类变量（强 vs. 弱 SoC，HR：1.08，95%CI：0.90-1.29）还是连续变量（HR：1.08；95%CI：1.00-1.17 每增加一个标准差的 SoC），与乳腺癌发病风险之间均无关联。总之，我们几乎没有证据支持 SoC 与乳腺癌发病风险之间存在关联。
