Division of Periodontology, Department of Oral Health Practice, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.
Division of Orthodontics, Department of Oral Health Sciences, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.
Periodontol 2000. 2021 Feb;85(1):161-181. doi: 10.1111/prd.12357. Epub 2020 Nov 23.
Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.
牙周炎是一种感染性、炎症性疾病，与特定细菌、宿主反应和环境因素之间的复杂相互作用有关。由于其具有高度的家族聚集性，特别是对于疾病的更具侵袭性形式，几十年来，遗传因素一直被认为与疾病的发病机制有关。这篇综述概述了我们目前对牙周病遗传和表观遗传贡献的了解，并讨论了该领域未来的机会。
