Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China.
State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Org Lett. 2020 Dec 4;22(23):9398-9403. doi: 10.1021/acs.orglett.0c03730. Epub 2020 Nov 23.
A silver-mediated internal alkyne-guided fluorination of unactivated C(sp)-H bonds is described. The reaction provides a facile access to γ-fluorinated fluoroalkylated ()-alkenes from readily available alkynes in promising yields with excellent regioselectivity, stereoselectivity, and site selectivity.
本文描述了一种银介导的未活化 C(sp)-H 键的内炔导向氟化反应。该反应提供了一种从易得的炔烃出发，以优异的区域选择性、立体选择性和位点选择性，以高收率获得γ-氟化全氟烷基化（）-烯烃的简便方法。
