未活化 C(sp)-H 键的内炔基导向氟代反应。
Internal Alkyne-Directed Fluorination of Unactivated C(sp)-H Bonds.
机构信息
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China.
State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
出版信息
Org Lett. 2020 Dec 4;22(23):9398-9403. doi: 10.1021/acs.orglett.0c03730. Epub 2020 Nov 23.
A silver-mediated internal alkyne-guided fluorination of unactivated C(sp)-H bonds is described. The reaction provides a facile access to γ-fluorinated fluoroalkylated ()-alkenes from readily available alkynes in promising yields with excellent regioselectivity, stereoselectivity, and site selectivity.
本文描述了一种银介导的未活化 C(sp)-H 键的内炔导向氟化反应。该反应提供了一种从易得的炔烃出发，以优异的区域选择性、立体选择性和位点选择性，以高收率获得γ-氟化全氟烷基化（）-烯烃的简便方法。
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