原甲藻酸，一种来自甲藻的神经活性超碳链化合物。
Prorocentroic Acid, a Neuroactive Super-Carbon-Chain Compound from the Dinoflagellate .
机构信息
Instituto Universitario de Bio-Orgánica Antonio González, University of La Laguna, 38206, Tenerife, Spain.
Department of Biochemistry and Molecular Biology and University Institute of Biotechnology of Asturias (IUBA), Campus "El Cristo", University of Oviedo, 33006 Oviedo, Oviedo, Spain.
出版信息
Org Lett. 2021 Jan 1;23(1):13-18. doi: 10.1021/acs.orglett.0c03437. Epub 2020 Nov 23.
Prorocentroic acid (PA) was isolated from the dinoflagellate Relative configurations for its 35 asymmetric centers were determined by analysis of NMR data including heteronuclear couplings and quantum mechanical calculations. PA was tested by using murine cortical neurons grown on microelectrode arrays. Long-term exposure to subtoxic concentrations induced a significant reorganization of neuronal signaling, mainly by changes in the bursting activity. The observed effects could be due to the activation of a plasticity process.
原甲藻酸（PA）从腰鞭毛目原生动物中分离得到。通过分析包括异核偶合和量子力学计算在内的 NMR 数据，确定了其 35 个不对称中心的相对构型。利用在微电极阵列上生长的鼠皮质神经元对 PA 进行了测试。长期暴露于亚毒性浓度会导致神经元信号的显著重组，主要通过爆发活动的变化来实现。观察到的效应可能是由于激活了一个可塑性过程。
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