斑点原甲藻中一种速效毒素——原甲藻毒素B的分离与结构
Isolation and structure of prorocentrolide B, a fast-acting toxin from Prorocentrum maculosum.
作者信息
Hu T, deFreitas A S, Curtis J M, Oshima Y, Walter J A, Wright J L
机构信息
Institute for Marine Biosciences, National Research Council of Canada, Halifax, Nova Scotia, Canada.
出版信息
J Nat Prod. 1996 Nov;59(11):1010-4. doi: 10.1021/np960439y.
A new toxin, prorocentrolide B (1), has been isolated following bioassay-guided fractionation of a BuOH extract of the tropical dinoflagellate, Prorocentrum maculosum Faust. This compound produces a rapid toxic response in the mouse bioassay, a type of activity not accounted for by other diarrhetic shellfish poisoning toxins produced by P. maculosum. The structure 1 was established by NMR and MS and is similar to prorocentrolide (2), a toxin from a strain of Prorocentrum lima. NMR data and the modeling program ConGen have been used to establish the relative stereochemistry of some individual ether ring systems and the hexahydroisoquinoline ring.
一种新毒素，原多甲藻素B（1），在对热带甲藻——具尾原多甲藻（Prorocentrum maculosum Faust）的丁醇提取物进行生物测定引导的分级分离后被分离出来。该化合物在小鼠生物测定中产生快速毒性反应，这种活性类型无法由具尾原多甲藻产生的其他腹泻性贝类中毒毒素来解释。通过核磁共振（NMR）和质谱（MS）确定了结构1，其与来自利马原多甲藻（Prorocentrum lima）菌株的毒素原多甲藻素（2）相似。核磁共振数据和建模程序ConGen已被用于确定一些单个醚环系统和六氢异喹啉环的相对立体化学。
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