Kalsow C M, Donoso L A
Department of Ophthalmology, University of Rochester, School of Medicine and Dentistry, NY 14642.
Curr Eye Res. 1987 Nov;6(11):1349-52. doi: 10.3109/02713688708997561.
S-antigen can elicit an experimental autoimmune uveitis (EAU) and pinealitis (EAP) in experimental animals. The sera of these animals have immunohistochemical reactivity with the photoreceptor cells of normal retina and pinealocytes. Lewis rats injected with the synthetic peptide-M corresponding to a specific sequence of S-antigen also develop an EAU and EAP. In this study we have investigated the immunohistochemical reactivity pattern of sera of guinea pigs injected with peptide-M. We found reactivity in the area of Muller's cells of normal guinea pig retina. Some of the sera showed weak reactivity with retina photoreceptors cells and pinealocytes. These patterns of reactivity are not seen in control sera of uninjected or saline in adjuvant injected guinea pigs. These results are consistent with observations of experimental and human uveitides.
S抗原可在实验动物中引发实验性自身免疫性葡萄膜炎（EAU）和松果体炎（EAP）。这些动物的血清与正常视网膜的光感受器细胞和松果体细胞具有免疫组织化学反应性。注射与S抗原特定序列相对应的合成肽-M的Lewis大鼠也会发生EAU和EAP。在本研究中，我们研究了注射肽-M的豚鼠血清的免疫组织化学反应模式。我们在正常豚鼠视网膜的Müller细胞区域发现了反应性。一些血清与视网膜光感受器细胞和松果体细胞表现出弱反应性。在未注射或注射佐剂生理盐水的豚鼠对照血清中未观察到这些反应模式。这些结果与实验性和人类葡萄膜炎的观察结果一致。
