Kalsow C M, Wacker W B
Invest Ophthalmol Vis Sci. 1978 Aug;17(8):774-83.
A form of experimental allergic uveitis (EAU) can be elicited in guinea pigs by injection of an extract of homologous retina homogenate (S preparation). These guinea pigs exhibit clinical and histological ocular disease as well as cellular and humoral immune responses to S preparation. Recent studies have shown an immunofluorescent crossreactivity of the sera of these animals (anti-S) with retinal photoreceptors and pinealocytes. The experiments presented in this paper demonstrate pineal gland involvement during the course of S preparation-induced EAU. There is lymphocytic infiltration of the pineal gland, with corresponding loss of antigen reactivity and some disturbance in cell structure. Pineal gland infiltrate can be seen before observable retinal involvement. Similarity of the reactive substances in retinal photoreceptors and pinealocytes is demonstrated by a reaction of identity in immunodiffusion studies and similar mobilities in immunoelectrophoretic studies of S preparation and pineal gland extract with anti-S serum. The relationship of the retinal and pineal substances to each other, as well as their role in disease development in the animal model and possibly in human uveitides, are discussed.
通过注射同源视网膜匀浆提取物（S制剂），可在豚鼠中引发一种实验性变应性葡萄膜炎（EAU）。这些豚鼠表现出临床和组织学上的眼部疾病，以及对S制剂的细胞免疫和体液免疫反应。最近的研究表明，这些动物的血清（抗S）与视网膜光感受器和松果体细胞存在免疫荧光交叉反应。本文所呈现的实验证明了在S制剂诱导的EAU病程中松果体的参与。松果体有淋巴细胞浸润，相应地抗原反应性丧失，细胞结构也有一些紊乱。在视网膜出现可观察到的病变之前就能看到松果体浸润。免疫扩散研究中的同一性反应以及S制剂和松果体提取物与抗S血清的免疫电泳研究中的相似迁移率，证明了视网膜光感受器和松果体细胞中反应性物质的相似性。本文还讨论了视网膜和松果体物质之间的关系，以及它们在动物模型疾病发展中以及可能在人类葡萄膜炎中的作用。
