State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People's Republic of China.
Chem Commun (Camb). 2020 Dec 8;56(96):15212-15215. doi: 10.1039/d0cc06645a.
Herein, we report the first protocol for visible-light-induced radical isocyanide insertion reactions between 3-(2-isocyanobenzyl)-indoles and bromodifluoroacetates or bromodifluoroacetamides. The protocol, which has good functional group tolerance and a broad substrate scope, constitutes an efficient and general route to difluoromethylated spiro[indole-3,3'-quinoline] derivatives.
在此，我们报告了首例可见光诱导的自由基异氰化物插入反应，涉及 3-(2-异氰基苄基)-吲哚与溴代二氟乙酸酯或溴代二氟乙酰胺。该方案具有良好的官能团耐受性和广泛的底物范围，是一种高效、通用的合成二氟甲基化螺[吲哚-3,3'-喹啉]衍生物的方法。
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