Ye Haiwei, Zhou Liping, Chen Yunhua, Tong Huaguang
Chemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Taizhou, 318000, P.R. China.
Taizhou Daozhi Tech Co., Ltd, Taizhou, 318000, P.R. China.
Org Biomol Chem. 2023 Jan 25;21(4):846-850. doi: 10.1039/d2ob02069f.
A visible-light-induced photocatalyst-free three-component radical tandem cyclization of -propargylamine and -allylbromodifluoroacetamides with the insertion of sulfur dioxide has been developed. Diverse difluoroamidosulfonylated quinolines are obtained in moderate to good yields. This protocol features broad functional group tolerance and high regioselectivity. Moreover, mechanistic studies reveal the involvement of the radical pathway and the formation of an electron donor-acceptor (EDA) complex in this reaction.
已开发出一种可见光诱导的、无光催化剂的三组分自由基串联环化反应，该反应涉及炔丙胺和烯丙基溴二氟乙酰胺与二氧化硫的插入反应。以中等至良好的产率获得了各种二氟酰胺基磺酰化喹啉。该方法具有广泛的官能团耐受性和高区域选择性。此外，机理研究揭示了该反应中自由基途径的参与以及电子供体-受体（EDA）络合物的形成。
