中国汉族人群中组蛋白去乙酰化酶9基因多态性与中风的关联。
Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population.
作者信息
Yang Xitong, Xu Hongyang, Liu Dan, Ma Rong, Zhang Yuanyuan, Wang Guangming
机构信息
Genetic Testing Center, The First Affiliated hospital of Dali University, Dali, China.
Deparment of Encephalopathy, Hospital of Traditional Chinese Medicine, Guangde, China.
出版信息
J Korean Neurosurg Soc. 2021 Mar;64(2):309-315. doi: 10.3340/jkns.2020.0040. Epub 2020 Nov 24.
OBJECTIVE
To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region.
METHODS
This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed.
RESULTS
In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited no significant difference between the two groups.
CONCLUSION
An association between rs723296 and the risk of IS was found in the Chinese Han population in Dali region. No significant association was found between rs1060499865, rs957960 and IS in the Chinese Han population in Dali region.
目的
探讨大理地区汉族人群中组蛋白去乙酰化酶9基因（rs1060499865、rs723296、rs957960）多态性与缺血性脑卒中（IS）的相关性。
方法
本研究纳入155例IS患者和128例健康体检者。采用TaqMan聚合酶链反应技术和多因素logistic回归分析。
结果
病例组中，两组均未观察到rs1060499865的多态性；而在rs723296位点，C等位基因和TC基因型的频率显著高于对照组，等位基因C和T使IS风险增加2.158倍，基因型TC和TT使IS风险增加2.269倍。rs957960位点两组间无显著差异。
结论
大理地区汉族人群中发现rs723296与IS风险相关。大理地区汉族人群中rs1060499865、rs957960与IS无显著相关性。
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