循环miR-17-92簇和HDAC9基因在伴有不稳定和稳定颈动脉斑块的动脉粥样硬化患者中的表达
Expression of Circulating miR-17-92 Cluster and HDAC9 Gene in Atherosclerotic Patients with Unstable and Stable Carotid Plaques.
作者信息
Ferronato Silvia, Mombello Aldo, Posenato Ilaria, Candiani Paola, Scuro Alberto, Setacci Carlo, Gomez-Lira Macarena
机构信息
1 Department of Neurological, Biomedical and Movement Sciences, University of Verona , Verona, Italy .
2 Department of Diagnostics and Public Health, University of Verona , Verona, Italy .
出版信息
Genet Test Mol Biomarkers. 2017 Jun;21(6):402-405. doi: 10.1089/gtmb.2016.0384. Epub 2017 Apr 24.
AIMS
The miR-17-92 cluster and the HDAC9 gene are involved in inflammatory, apoptotic, and angiogenic processes that are activated in the vulnerable carotid plaque. The aim of this research was to determine whether expression of one or more of the miRs of the miR-17-92 cluster and/or HDAC9 expression could represent biomarkers for patients with unstable atherosclerotic carotid plaques.
MATERIALS AND METHODS
Plasma levels of miRs and HDAC9 expression in peripheral blood were analyzed by real-time PCR in patients with histologically classified stable or unstable plaques.
RESULTS
No differences were observed between the two groups.
DISCUSSION AND CONCLUSIONS
Levels of the miR-17-92 cluster in plasma and HDAC9 gene expression in peripheral blood cannot be considered appropriate biomarkers to identify patients with unstable plaques at risk of rupture.
目的
miR-17-92簇和HDAC9基因参与了在易损颈动脉斑块中被激活的炎症、凋亡和血管生成过程。本研究的目的是确定miR-17-92簇中一个或多个miR的表达和/或HDAC9表达是否可作为不稳定动脉粥样硬化颈动脉斑块患者的生物标志物。
材料与方法
通过实时PCR分析组织学分类为稳定或不稳定斑块患者外周血中miR的血浆水平和HDAC9表达。
结果
两组之间未观察到差异。
讨论与结论
血浆中miR-17-92簇的水平和外周血中HDAC9基因的表达不能被视为识别有破裂风险的不稳定斑块患者的合适生物标志物。
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