超氧化物歧化酶基因多态性与中国大理地区汉族人群缺血性卒中风险相关。

Superoxide Dismutase Gene Polymorphism is Associated With Ischemic Stroke Risk in the China Dali Region Han Population.

机构信息

Genetic Testing Center, The First Affiliated Hospital of Dali University, Dali, Yunnan.

Hospital of Traditional Chinese Medicine Guangde, Guangde, Anhui, China.

出版信息

Neurologist. 2021 Mar 4;26(2):27-31. doi: 10.1097/NRL.0000000000000301.

DOI:10.1097/NRL.0000000000000301

PMID:33646985

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8041563/

Abstract

BACKGROUND

Stroke is a serious cardiovascular disease, a major cause of disability and death in both developed and developing countries. Superoxide dismutases (SODs) are enzymes that catalyze the breakdown of superoxide into oxygen and hydrogen peroxide and play a key role in the antioxidant response. This study explored the relationship between single-nucleotide polymorphisms (SNPs) in SOD genes and the risk of ischemic stroke (IS) in the Chinese Han population of Dali City.

METHODS

For this case-control study, the authors enrolled 144 patients who had an IS and 128 healthy controls. The SNPs rs17880487 and rs80265967 of the SOD1 gene, rs4880 and rs2842960 of the SOD2 gene, and rs2695232 and rs7655372 of the SOD3 gene were detected through TaqMan polymerase chain reaction. Genotypes and allele frequencies of the 2 groups were compared. Odds ratio and 95% confidence intervals were calculated by unconditional logistic regression, and environmental factors were corrected with multivariate logistic regression analysis.

RESULTS

Rs7655372 of SOD3 was associated with a significantly increased risk of IS. Moreover, the A and GA genotypes of SNP rs7655372 were associated with increased risk of IS, whereas the A and GA genotypes were risk factors for IS. Furthermore, multivariate logistic regression analysis showed that the rs7655372 GA genotype is the independent risk factor for IS.

CONCLUSION

The SOD3 gene rs7655372 locus polymorphism is a risk factor for IS in the Dali region.

摘要

背景

卒中是一种严重的心血管疾病，在发达国家和发展中国家都是导致残疾和死亡的主要原因。超氧化物歧化酶（SODs）是一种能够催化超氧化物分解为氧和过氧化氢的酶，在抗氧化反应中起着关键作用。本研究旨在探讨 SOD 基因单核苷酸多态性（SNPs）与大理市汉族人群缺血性卒中（IS）风险的关系。

方法

本病例对照研究共纳入 144 例 IS 患者和 128 名健康对照者。采用 TaqMan 聚合酶链反应检测 SOD1 基因 rs17880487 和 rs80265967、SOD2 基因 rs4880 和 rs2842960 以及 SOD3 基因 rs2695232 和 rs7655372 的 SNP。比较两组的基因型和等位基因频率。采用非条件 logistic 回归计算比值比和 95%置信区间，并采用多因素 logistic 回归分析校正环境因素。

结果

SOD3 的 rs7655372 与 IS 的发病风险显著相关。此外，SNP rs7655372 的 AA 和 GA 基因型与 IS 发病风险增加相关，而 AA 和 GA 基因型是 IS 的危险因素。进一步的多因素 logistic 回归分析显示，rs7655372GA 基因型是 IS 的独立危险因素。