de Martin R, Haendler B, Hofer-Warbinek R, Gaugitsch H, Wrann M, Schlüsener H, Seifert J M, Bodmer S, Fontana A, Hofer E
Sandoz Forschungsinstitut, Wien, Austria.
EMBO J. 1987 Dec 1;6(12):3673-7. doi: 10.1002/j.1460-2075.1987.tb02700.x.
Human glioblastoma cells secrete a peptide, termed glioblastoma-derived T cell suppressor factor (G-TsF), which has suppressive effects on interleukin-2-dependent T cell growth. As shown here, complementary DNA for G-TsF reveals that G-TsF shares 71% amino acid homology with transforming growth factor-beta (TGF-beta). In analogy to TGF-beta it is apparently synthesized as the carboxy-terminal end of a precursor polypeptide which undergoes proteolytic cleavage to yield the 112 amino-acid-long mature form of G-TsF. Comparison of the amino-terminal sequence of G-TsF with that of porcine TGF-beta 2 and bovine cartilage-inducing factor B shows complete homology, which indicates that we have cloned the human analogue of these factors. It is tempting to consider a role for G-TsF in tumor growth where it may enhance tumor cell proliferation in an autocrine way and/or reduce immunosurveillance of tumor development.
人胶质母细胞瘤细胞分泌一种名为胶质母细胞瘤衍生的T细胞抑制因子（G-TsF）的肽，它对白细胞介素-2依赖的T细胞生长具有抑制作用。如下所示，G-TsF的互补DNA显示，G-TsF与转化生长因子-β（TGF-β）有71%的氨基酸同源性。与TGF-β类似，它显然以前体多肽的羧基末端形式合成，该前体多肽经过蛋白水解切割，产生112个氨基酸长的G-TsF成熟形式。G-TsF的氨基末端序列与猪TGF-β2和牛软骨诱导因子B的氨基末端序列比较显示完全同源，这表明我们已经克隆了这些因子的人类类似物。很容易想到G-TsF在肿瘤生长中的作用，它可能以自分泌方式增强肿瘤细胞增殖和/或降低对肿瘤发生的免疫监视。
