TNF-α G-308A 启动子多态性与 COVID-19 患者病程和转归的关联。
Association of TNF-α G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients.
机构信息
Department of Internal Medicine, Hepatology & Gastroenterology Unit, Faculty of Medicine, Mansoura University, Al Mansurah, Egypt.
Department of Clinical Pathology, Haematology Unit, Faculty of Medicine, Mansoura University, Al Mansurah, Egypt.
出版信息
Immunol Invest. 2022 Apr;51(3):546-557. doi: 10.1080/08820139.2020.1851709. Epub 2020 Nov 23.
BACKGROUND
Tumor necrosis factor-ɑ (TNF-ɑ) is one of the most important cytokines that manage the host defense mechanism, which may play a role in the pathogenesis of COVID-19 patients. The work aims to study the association of TNF-ɑ G-308 A gene polymorphism with the course and outcome of COVID-19 patients in Mansoura University Hospital.
METHODS
900 patients with COVID-19 infection and 184 controls were tested for TNF-ɑ G-308 A promoter polymorphism. Different genotypes of TNF-ɑ G-308 A were compared as regards the severity and prognosis of the disease.
RESULTS
No statistically significant difference was found between patients and controls as regards the demographic data. The AA genotype of TNF-ɑ showed a higher incidence of the disease in comparison to the other genotypes. As regards the demographic and laboratory characters, no statistically significant difference was found between the different genotypes except for age, lymphopenia, CRP, and serum ferritin levels. In 336(80.0%) cases of the AA genotype, the disease was severe in comparison to 90(41.7%) cases in the GA genotype and no cases in the GG genotype with = .001.
CONCLUSION
People who carry the A allele of TNF-ɑ polymorphism are more prone to COVID-19 infection. The AA genotype of TNF-ɑ is associated with a more aggressive pattern of the disease. In those patients, the use of anti - TNF therapy may be promising.
背景
肿瘤坏死因子-α（TNF-α）是管理宿主防御机制的最重要细胞因子之一，它可能在 COVID-19 患者的发病机制中发挥作用。本研究旨在探讨 TNF-α G-308 A 基因多态性与曼苏拉大学医院 COVID-19 患者病程和结局的关系。
方法
对 900 例 COVID-19 感染患者和 184 名对照者进行 TNF-α G-308 A 启动子多态性检测。比较不同 TNF-α G-308 A 基因型与疾病严重程度和预后的关系。
结果
患者与对照组在人口统计学数据方面无统计学差异。TNF-α 的 AA 基因型与其他基因型相比，疾病发生率更高。在人口统计学和实验室特征方面，除年龄、淋巴细胞减少、CRP 和血清铁蛋白水平外，不同基因型之间无统计学差异。在 336 例（80.0%）AA 基因型患者中，疾病严重程度高于 GA 基因型的 90 例（41.7%），而 GG 基因型无病例，=0.001。
结论
携带 TNF-α 多态性 A 等位基因的人更容易感染 COVID-19。TNF-α 的 AA 基因型与疾病更具侵袭性的模式相关。在这些患者中，使用抗 TNF 治疗可能有希望。
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