Division of Pediatric Dermatology, Johns Hopkins Medical Institutions, 200 N. Wolfe Street, Baltimore, MD 21287, USA.
Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA.
Pediatr Clin North Am. 2021 Feb;68(1):261-276. doi: 10.1016/j.pcl.2020.09.009.
Systemic diseases often manifest with cutaneous findings. Many pediatric conditions with prominent skin findings also have significant pulmonary manifestations. These conditions include both inherited multisystem genetic disorders such as yellow-nail syndrome, neurofibromatosis type 1, tuberous sclerosis complex, hereditary hemorrhagic telangiectasia, Klippel-Trénaunay-Weber syndrome, cutis laxa, Ehlers-Danlos syndrome, dyskeratosis congenita, reactive processes such as mastocytosis, and aquagenic wrinkling of the palms. This overview discusses the pulmonary manifestations of skin disorders.
系统性疾病常表现为皮肤表现。许多以明显皮肤表现为特征的儿科疾病也有显著的肺部表现。这些疾病包括遗传性多系统遗传疾病，如黄甲综合征、神经纤维瘤病 1 型、结节性硬化症、遗传性出血性毛细血管扩张症、Klippel-Trénaunay-Weber 综合征、弹力纤维假黄瘤、埃勒斯-当洛斯综合征、先天性角化不良、反应性疾病，如肥大细胞增多症和手掌水变性皱纹。本文综述了皮肤疾病的肺部表现。
