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[胆源性胰腺炎中胆石症的早期治疗]

[Early treatment of biliary lithiasis in biliary pancreatitis].

作者信息

Belghiti J, Kleinman P, Cherqui D, Perniceni T, Bernades P, Fékété F

机构信息

Service de Chirurgie Digestive, Hôpital Beaujon, Clichy.

出版信息

Gastroenterol Clin Biol. 1987 Nov;11(11):786-9.

PMID:3322925
Abstract

Since 1982, 38 consecutive patients with biliary pancreatitis were treated prospectively in order to prevent recurrent migration of gallstones. Removal of the stones was achieved by "early surgery" i. e. within the first week after admission or by endoscopic sphincterotomy in patients with severe pancreatitis. Gallstones were visualized by ultrasonography in 31 patients (82 p. 100). Microlithiasis was present in 14 (37 p. 100) and was missed at ultrasonography in 7 patients. According to Ranson's prognostic signs, only 4 patients had 4 or more signs. These 4 patients and 2 additional patients aged more than 85 underwent urgent retrograde cholangiography and endoscopic sphincterotomy. No complications could be attributed to this technique. Among the 4 patients with severe pancreatitis, 3 developed an abscess which required delayed surgery without further complications. The 32 other patients underwent a biliary operation within the first week after admission. Common bile duct calculi were present in 14 patients being discovered by cholangioscopy in 6. One patient died after operation and one was reoperated on for a pseudocyst on day 40. No recurrent attack of pancreatitis was observed in either group. Our study suggests that slightly delayed biliary operation with cholangioscopy during the same hospitalization can be performed safety in patients with mild pancreatitis. In patients with severe attack and/or poor general condition, endoscopic sphincterotomy is a safe technique and deserves wider consideration in the management of severe acute pancreatitis for which delayed drainage of pancreatic necrosis may occasionally be required.

摘要

自1982年以来,对38例连续性胆源性胰腺炎患者进行了前瞻性治疗,以防止胆结石反复移动。通过“早期手术”,即在入院后第一周内进行手术,或对重症胰腺炎患者进行内镜括约肌切开术来取出结石。31例患者(82%)通过超声检查发现胆结石。14例(37%)存在微结石,其中7例超声检查未发现。根据兰森预后指标,只有4例患者有4个或更多指标。这4例患者和另外2例年龄超过85岁的患者接受了紧急逆行胆管造影和内镜括约肌切开术。该技术未导致任何并发症。在4例重症胰腺炎患者中,3例出现脓肿,需要延期手术,未出现进一步并发症。其他32例患者在入院后第一周内接受了胆道手术。14例患者存在胆总管结石,其中6例通过胆管镜检查发现。1例患者术后死亡,1例患者在第40天因假性囊肿再次手术。两组均未观察到胰腺炎复发。我们的研究表明,对于轻度胰腺炎患者,在同一住院期间稍延迟进行胆管镜检查的胆道手术可安全进行。对于重症发作和/或全身状况较差的患者,内镜括约肌切开术是一种安全的技术,在重症急性胰腺炎的治疗中值得更广泛考虑,因为有时可能需要延迟引流胰腺坏死。

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