Zhao Xiao Qi, Ao Ying, Chen Hai Yun, Wang Hui
Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China.
Yi Chuan. 2020 Nov 20;42(11):1062-1072. doi: 10.16288/j.yczz.20-112.
MicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including organ development. Recent studies have shown that some miRNAs are highly expressed in the kidney and are closely related to kidney development and diseases, suggesting that miRNAs are important regulators in kidney physiology and pathology. This review will focus on the research progress of miRNA in kidney development, and discuss the role of miRNAs in the occurrence and development of renal dysplasia, which will provide a reference for the diagnosis and research of diseases related to kidney development.
微小RNA（miRNA）是内源性小非编码RNA（19 - 25个核苷酸），通过与靶mRNA中的互补靶序列结合，在转录后水平负调控基因表达。miRNA在包括器官发育在内的广泛生物学过程中发挥重要作用。最近的研究表明，一些miRNA在肾脏中高度表达，并且与肾脏发育和疾病密切相关，这表明miRNA是肾脏生理和病理中的重要调节因子。本综述将聚焦于miRNA在肾脏发育方面的研究进展，并探讨miRNA在肾发育异常发生和发展中的作用，这将为与肾脏发育相关疾病的诊断和研究提供参考。
