皮肤Ⅰ型干扰素在自身免疫和自身炎症性疾病中的作用。
The Role of Cutaneous Type I IFNs in Autoimmune and Autoinflammatory Diseases.
机构信息
Department of Pediatrics, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109; and.
Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109
出版信息
J Immunol. 2020 Dec 1;205(11):2941-2950. doi: 10.4049/jimmunol.2000596.
IFNs are well known as mediators of the antimicrobial response but also serve as important immunomodulatory cytokines in autoimmune and autoinflammatory diseases. An increasingly critical role for IFNs in evolution of skin inflammation in these patients has been recognized. IFNs are produced not only by infiltrating immune but also resident skin cells, with increased baseline IFN production priming for inflammatory cell activation, immune response amplification, and development of skin lesions. The IFN response differs by cell type and host factors and may be modified by other inflammatory pathway activation specific to individual diseases, leading to differing clinical phenotypes. Understanding the contribution of IFNs to skin and systemic disease pathogenesis is key to development of new therapeutics and improved patient outcomes. In this review, we summarize the immunomodulatory role of IFNs in skin, with a focus on type I, and provide insight into IFN dysregulation in autoimmune and autoinflammatory diseases.
干扰素作为抗菌反应的介质而广为人知，但在自身免疫和自身炎症性疾病中也作为重要的免疫调节细胞因子发挥作用。人们越来越认识到，在这些患者的皮肤炎症演变过程中，IFN 起着至关重要的作用。IFN 不仅由浸润性免疫细胞产生，也由固有皮肤细胞产生，基础 IFN 产生增加可促使炎症细胞激活、免疫反应放大和皮肤损伤发展。IFN 反应因细胞类型和宿主因素而异，并且可能被特定于个体疾病的其他炎症途径激活所改变，导致不同的临床表型。了解 IFN 对皮肤和全身疾病发病机制的贡献是开发新疗法和改善患者预后的关键。在这篇综述中，我们总结了 IFN 在皮肤中的免疫调节作用，重点介绍了 I 型 IFN，并深入探讨了自身免疫和自身炎症性疾病中 IFN 的失调。
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