School of Medicine.
Department of Ophthalmology.
Ophthalmic Plast Reconstr Surg. 2021;37(2):e40-e80. doi: 10.1097/IOP.0000000000001889.
Acute invasive fungal rhinosinusitis is a rare, although highly morbid, infection primarily affecting immunosuppressed individuals. The same population is at particularly high risk of complications and mortality in the setting of SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. The authors present a case of acute invasive fungal rhino-orbital mucormycosis in a patient with COVID-19 and discuss the prevalence, diagnosis, and treatment of fungal coinfections in COVID-19. Prompt recognition, initiation of therapy, and consideration of the challenges of rapidly evolving COVID-19 therapy guidelines are important for improving patient survival.
急性侵袭性真菌性鼻-眶-脑真菌病是一种罕见但高度致命的感染，主要影响免疫抑制个体。在 SARS-CoV-2 感染和与 2019 年冠状病毒病（COVID-19）相关的急性呼吸窘迫综合征的情况下，同一人群发生并发症和死亡的风险特别高。作者报告了一例 COVID-19 患者的急性侵袭性真菌性鼻-眶-脑毛霉病，并讨论了 COVID-19 中真菌合并感染的流行率、诊断和治疗。及时识别、开始治疗以及考虑到 COVID-19 治疗指南快速演变的挑战，对于提高患者生存率非常重要。
