Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family Department of Ophthalmology, UC San Diego Shiley Eye Institute, La Jolla, California, USA.
Division of Plastic and Reconstructive Surgery, Department of Surgery, UC San Diego, La Jolla, California, USA.
Orbit. 2022 Oct;41(5):616-619. doi: 10.1080/01676830.2021.1903044. Epub 2021 Mar 23.
We report two fatal cases of rhino-orbital-cerebral mucormycosis associated with COVID-19 infection. Both patients had pre-existing diabetes mellitus type 2, were treated with corticosteroids, and developed ketoacidosis. Both patients rapidly declined owing to rapid extension of the infection into the intracranial cavity. We postulate that additional risk factors for opportunistic fungal infection exist in COVID-19 patients including mechanical ventilation and Sars-CoV-2 induced immunosuppression. The ophthalmologist's role is particularly important in the early diagnosis of mucormycosis associated with COVID-19.
我们报告了两例与 COVID-19 感染相关的鼻眶脑毛霉病致死病例。这两例患者均患有 2 型糖尿病，接受了皮质类固醇治疗，并发生了酮症酸中毒。由于感染迅速向颅内扩展，这两例患者均迅速恶化。我们推测 COVID-19 患者存在机会性真菌感染的其他危险因素，包括机械通气和 SARS-CoV-2 诱导的免疫抑制。眼科医生在早期诊断 COVID-19 相关毛霉病方面发挥着重要作用。
