Ity/Lsh/Bcg基因显著影响小鼠对鼠麻风杆菌的抵抗力。
The Ity/Lsh/Bcg gene significantly affects mouse resistance to Mycobacterium lepraemurium.
作者信息
Brown I N, Glynn A A
机构信息
St Mary's Hospital Medical School, London, U.K.
出版信息
Immunology. 1987 Dec;62(4):587-91.
Mouse resistance to infection with Mycobacterium lepraemurium was measured by counting the total number of intact acid-fast bacilli in the spleen 8 weeks after i.v. injection of a standard inoculation. The effect of Ityr on resistance to M. lepraemurium was confirmed and the results extended to two Ityr strains of mice, A and C57L, not previously tested. Resistance to M. lepraemurium was also examined in the F1, backcross and F2 generations of BALB/c X CBA crosses, and in the congenic strain B10.LLshr that is Ityr. In all experiments the results were consistent with the view that resistance to M. lepraemurium is significantly affected by a gene close to or identical to the Ity/Lsh/Bcg gene on mouse chromosome 1. Sex had a marked effect on resistance to M. lepraemurium, so that the males of some genetically resistant strains were almost as susceptible as some genetically susceptible females.
通过静脉注射标准接种物8周后，对脾脏中完整抗酸杆菌的总数进行计数，来测定小鼠对鼠麻风杆菌感染的抵抗力。证实了Ityr对鼠麻风杆菌抵抗力的影响，并将结果扩展到两种先前未测试过的Ityr小鼠品系A和C57L。还在BALB/c×CBA杂交的F1、回交和F2代以及同源品系B10.LLshr（即Ityr）中检测了对鼠麻风杆菌的抵抗力。在所有实验中，结果均与以下观点一致：对鼠麻风杆菌的抵抗力受到小鼠1号染色体上与Ity/Lsh/Bcg基因接近或相同的一个基因的显著影响。性别对鼠麻风杆菌的抵抗力有显著影响，因此一些遗传抗性品系的雄性几乎与一些遗传易感雌性一样易感。
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