Skamene E, Gros P, Forget A, Patel P J, Nesbitt M N
Immunogenetics. 1984;19(2):117-24. doi: 10.1007/BF00387854.
Mice of different inbred strains vary in their resistance to intravenous infection with Mycobacterium lepraemurium (MLM). The mean survival time of MLM-infected A/J and DBA/2 mice is significantly longer than that of similarly infected C57BL/6 and BALB/c mice. The typing of AXB/BXA recombinant inbred strains (A = A/J,B = C57BL/6) for the trait of relative resistance/susceptibility to MLM revealed a perfect match with the strain distribution pattern of resistance/susceptibility to Mycobacterium bovis (BCG), the trait which is controlled by the Bcg (Ity, Lsh) locus on chromosome 1. The control, by this gene, of response to MLM was further confirmed by the demonstration that BALB/c-Bcgr congenic mice, which carry the DBA/2-derived Bcgr (resistant) allele on chromosome 1, are significantly more resistant to MLM infection than their BALB/c (Bcgs, susceptible) counterparts.
不同近交系小鼠对鼠麻风杆菌（MLM）静脉感染的抵抗力有所不同。感染MLM的A/J和DBA/2小鼠的平均存活时间明显长于同样感染的C57BL/6和BALB/c小鼠。对AXB/BXA重组近交系（A = A/J，B = C57BL/6）进行对MLM相对抗性/易感性性状的分型，结果显示与对牛分枝杆菌（BCG）抗性/易感性的品系分布模式完全匹配，该性状由1号染色体上的Bcg（Ity，Lsh）位点控制。通过证明携带1号染色体上DBA/2来源的Bcgr（抗性）等位基因的BALB/c - Bcgr同源基因小鼠比其BALB/c（Bcgs，易感）同窝小鼠对MLM感染具有明显更高的抗性，进一步证实了该基因对MLM反应的控制作用。
