Iesa M A M, Osman M E M, Hassan M A, Dirar A I A, Abuzeid N, Mancuso J J, Pandey R, Mohammed A A, Borad M J, Babiker H M, Konozy E H E
Department of Physiology, Al Qunfudah Medical College, Umm Al Qura University, Mecca, Saudi Arabia.
Department of Zoology, Faculty of Science, University of Khartoum, Khartoum, Sudan.
New Microbes New Infect. 2020 Nov;38:100817. doi: 10.1016/j.nmni.2020.100817. Epub 2020 Nov 19.
Coronavirus disease 2019 (COVID-19) has caused significant morbidity and mortality and new cases are on the rise globally, yet malaria-endemic areas report statistically significant lower incidences. We identified potential shared targets for an immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by immune determinants' shared identities with using the Immune Epitope Database and Analysis Resource Immune 9.0 browser tool. Probable cross-reactivity is suggested through HLA-A∗02:01 and subsequent CD8 T-cell activation. The apparent immunodominant epitope conservation between SARS-CoV-2 (N and open reading frame (ORF) 1ab) and thrombospondin-related anonymous protein (TRAP) may underlie the low COVID-19 incidence in the malaria-endemic zone by providing immunity against virus infection to those previously infected with . Additionally, we hypothesize that the shared epitopes which lie within antigens that aid in the establishment of the erythrocyte invasion may be an alternative route for SARS-CoV-2 via the erythrocyte CD147 receptor, although this remains to be proven.
2019冠状病毒病（COVID-19）已导致大量发病和死亡，全球新病例数正在上升，但疟疾流行地区报告的发病率在统计学上显著较低。我们通过使用免疫表位数据库和分析资源免疫9.0浏览器工具，根据免疫决定因素的共享身份，确定了针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）免疫反应的潜在共同靶点。通过HLA-A∗02:01和随后的CD8 T细胞激活提示可能存在交叉反应性。SARS-CoV-2（N和开放阅读框（ORF）1ab）与血小板反应蛋白相关无名蛋白（TRAP）之间明显的免疫显性表位保守性，可能通过为先前感染过[某种病原体]的人提供抗病毒感染免疫力，从而成为疟疾流行区COVID-19发病率低的原因。此外，我们假设，位于有助于疟原虫建立红细胞入侵的抗原内的共享表位，可能是SARS-CoV-2通过红细胞CD147受体入侵的另一条途径，尽管这仍有待证实。
