Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Turkey.
Faculty of Medicine, Anesthesiology and Reanimation Intensive Care Unit, Ege University, Bornova, Turkey.
Eur J Clin Microbiol Infect Dis. 2021 Mar;40(3):615-622. doi: 10.1007/s10096-019-03789-4. Epub 2020 Nov 24.
The aim of this study was to investigate the effect of oropharyngeal aspiration on ventilator-associated pneumonia (VAP) incidence just prior to changing patient position. This randomized controlled experimental study was conducted between July 2015 and April 2019 in anesthesiology and reanimation of intensive care unit (ICU). The patients of experimental group underwent oropharyngeal aspiration under surgical aseptic conditions before each position change. Patients of the control group received oropharyngeal aspiration only as needed. The mean age of the patients was 62.87 ± 17.33 years. The mean and median duration of stay in the ICU were 27.28 ± 30.69 and 18.00 days respectively. The mean and median of duration of the mechanical ventilation support were 26.72 ± 30.65 and 18.00 (min 4; max 168) days respectively. Thirty percent of the patients were VAP. The mean duration of VAP development was 7.50 ± 5.07 days. The rate of VAP development was 11.23/1000 mechanical ventilator days. Only 8.3% of the experimental group patients developed VAP; 91.7% of the control group patients developed VAP. The VAP rate in the control group was 16.82/1000 mechanical ventilator days and the VAP rate in the experimental group was 2.41/1000 mechanical ventilator days. Most VAP agents were multidrug resistant. Distribution of isolated microorganisms was as Acinetobacter baumannii, Pseudomonas aeruginosa, Corynebacterium striatum, Staphylococcus aureus, Providencia stuartii, Serratia marcescens, Stenotrophomonas maltophilia, and Aspergillus flavus. In our study, it was concluded that oropharyngeal aspiration performed prior to patient position change prevented the development of VAP.
本研究旨在探讨在改变患者体位前进行口咽抽吸对呼吸机相关性肺炎(VAP)发生率的影响。这是一项在麻醉学和重症监护病房(ICU)进行的随机对照实验研究,时间为 2015 年 7 月至 2019 年 4 月。实验组患者在每次体位改变前在手术无菌条件下进行口咽抽吸,对照组患者仅在需要时进行口咽抽吸。患者的平均年龄为 62.87±17.33 岁。患者在 ICU 的平均和中位数住院时间分别为 27.28±30.69 天和 18.00 天。机械通气支持的平均和中位数持续时间分别为 26.72±30.65 天和 18.00(分钟 4;最大 168)天。30%的患者患有 VAP。VAP 发展的平均持续时间为 7.50±5.07 天。VAP 发展的发生率为 11.23/1000 机械通气天数。实验组患者中只有 8.3%发生 VAP,对照组患者中 91.7%发生 VAP。对照组 VAP 发生率为 16.82/1000 机械通气天数,实验组 VAP 发生率为 2.41/1000 机械通气天数。大多数 VAP 病原体为多药耐药菌。分离微生物的分布为鲍曼不动杆菌、铜绿假单胞菌、棒状杆菌、金黄色葡萄球菌、斯氏普罗维登斯菌、粘质沙雷菌、嗜麦芽窄食单胞菌和黄曲霉。在我们的研究中,我们得出结论,在改变患者体位前进行口咽抽吸可预防 VAP 的发生。