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北方的A型和B型肉毒中毒:阿拉斯加因纽特人中首次报告的非E型毒素所致病例。

Type A and type B botulism in the North: first reported cases due to toxin other than type E in Alaskan Inuit.

作者信息

Barrett D H, Eisenberg M S, Bender T R, Burks J M, Hatheway C L, Dowell V R

出版信息

Can Med Assoc J. 1977 Sep 3;117(5):483-9.

PMID:332309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1879961/
Abstract

Botulism outbreaks shown to be due to type A and type B toxin occurred in Alaska, a region previously known for only type E botulism. The outbreak due to type A toxin involved three people, two of whom died. The outbreak due to type B toxin involved nine people, none of whom died. Both outbreaks were in Inuit villages, and native foods were incriminated. The occurrence of these outbreaks strongly suggests that Clostridium botulinum, types A and B are indigenous to Alaska. The outbreaks underscore the need for initial treatment of patients with antitoxin that is trivalent (ABE), even in Arctic regions.

摘要

肉毒中毒疫情显示,在阿拉斯加发生了由A型和B型毒素引起的疫情,该地区此前仅以E型肉毒中毒而闻名。由A型毒素引起的疫情涉及三人,其中两人死亡。由B型毒素引起的疫情涉及九人,无人死亡。两次疫情均发生在因纽特人村庄,当地食物被认定为罪魁祸首。这些疫情的发生强烈表明,A型和B型肉毒杆菌在阿拉斯加是本土存在的。这些疫情凸显了即使在北极地区,也需要用三价(ABE)抗毒素对患者进行初始治疗。

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本文引用的文献

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Fatal Outbreak of Botulism among Labrador Eskimos.拉布拉多因纽特人中肉毒中毒的致命疫情。
Br Med J. 1957 Oct 19;2(5050):924. doi: 10.1136/bmj.2.5050.924.
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Syndrome of botulism in infancy: clinical and electrophysiologic study.婴儿肉毒中毒综合征:临床与电生理研究
N Engl J Med. 1976 Sep 30;295(14):770-2. doi: 10.1056/NEJM197609302951407.