Fagan Ryan P, McLaughlin Joseph B, Middaugh John P
Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Infect Dis. 2009 Apr 1;199(7):1029-31. doi: 10.1086/597310.
Persistence of circulating toxin in patients with foodborne botulism is not well characterized. Recommendations for administration of botulinum antitoxin are ambiguous for patients with late-presenting disease, such as a Florida woman with toxin-positive serum 12 days after toxin ingestion. We reviewed Alaska records of foodborne outbreaks of botulism that occurred during 1959-2007 to examine the period after ingestion during which toxin was detected. Of 64 cases with toxin-positive serum, toxin was detected up to 11 days after ingestion. The findings from Alaska and Florida support administration of antitoxin up to 12 days after toxin ingestion but do not indicate when circulating toxin should no longer be present.
食源性肉毒中毒患者体内循环毒素的持续存在情况尚未得到充分描述。对于出现较晚的疾病患者，如一名佛罗里达女性在摄入毒素12天后血清毒素呈阳性，肉毒抗毒素的给药建议并不明确。我们回顾了1959 - 2007年阿拉斯加食源性肉毒中毒暴发的记录，以研究摄入毒素后可检测到毒素的时间段。在64例血清毒素呈阳性的病例中，摄入毒素后长达11天仍可检测到毒素。阿拉斯加和佛罗里达的研究结果支持在摄入毒素后12天内给予抗毒素，但并未表明循环毒素何时应不再存在。
