Dolman C E
Can Med Assoc J. 1974 Jan 19;110(2):191-7 passim.
Since 1919, in Canada, 62 authenticated outbreaks of human botulism have affected 181 persons, with 83 deaths, a fatality rate of 46%. Among these, 41 outbreaks were bacteriologically determined (31 in one laboratory) as six type A, four type B, one both A and B, and 30 type E. About two thirds of the total outbreaks, cases and deaths involved Eskimos and Pacific coast Indians consuming raw marine mammal products and salmon eggs, respectively. Other parts of Canada recorded seven occurrences due to miscellaneous vehicles, three being type B. Since January 1961 there have been 38 outbreaks, involving 94 cases with 33 deaths. These include 18 outbreaks among Eskimos, affecting 51 persons (of whom 24 died) in Labrador, southern Baffin Island, northern Quebec, and the Mackenzie area. Also, putrid salmon eggs caused 15 outbreaks among Pacific coast Indians, totalling 35 cases, of whom only six died, the low fatality rate reflecting the introduction of type E botulinus antitoxin during 1961.
自1919年以来,加拿大已发生62起经证实的人类肉毒中毒疫情,涉及181人,其中83人死亡,病死率为46%。其中,41起疫情经细菌学确定(31起在一个实验室),分别为6起A型、4起B型、1起A和B型混合,以及30起E型。疫情、病例和死亡总数的约三分之二分别涉及食用生海洋哺乳动物产品的爱斯基摩人和食用鲑鱼卵的太平洋沿岸印第安人。加拿大其他地区因多种传播媒介记录了7起疫情,其中3起为B型。自1961年1月以来,共发生38起疫情,涉及94例病例,33人死亡。其中包括18起发生在爱斯基摩人中的疫情,影响了拉布拉多、巴芬岛南部、魁北克北部和麦肯齐地区的51人(其中24人死亡)。此外,变质的鲑鱼卵在太平洋沿岸印第安人中引发了15起疫情,共计35例病例,其中仅6人死亡,低病死率反映了1961年期间引入了E型肉毒抗毒素。