Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Department of Occupational and Environmental Medicine, Inha University College of Medicine, Incheon, Korea.
J Korean Med Sci. 2020 Nov 23;35(45):e377. doi: 10.3346/jkms.2020.35.e377.
To compare the chest computed tomography (CT) images of children and adults in families with clusters of humidifier disinfectant-related lung injury (HDLI) after cessation of exposure to humidifier disinfectant (HD).
We reviewed medical records of 19 families with 43 patients (21 adults, 22 children) among families, which had at least one adult and one child with HDLI. Each family was exposed to the same HD exposure environment.
In adults, centrilobular nodules were predominant (95.2%) in chronic HDLI findings after cessation of exposure to HD, however, in children, normal pattern was most prevalent on chest CT (45.5%), followed by centrilobular nodule (36.4%), bizarre lung cysts (36.4%), and reticulation (13.6%).
Unlike the known chronic HDLI finding of adults, centrilobular nodules were only present in 36.4% of children. The frequency of bizarre lung cysts were significantly greater in children than that in adults after cessation of similar exposure to HD. Thus, bizarre lung cysts may be useful as another novel finding of chronic HDLI in children who have no history of pulmonary infection or other perinatal disorder such as hyaline membrane disease or other interstitial lung disease.
比较停止使用加湿器消毒剂（HD）后集群性加湿器消毒剂相关肺损伤（HDLI）患儿和成人的胸部计算机断层扫描（CT）图像。
我们回顾了 19 个家庭的医疗记录，这些家庭中有 43 名患者（21 名成人，22 名儿童），每个家庭都暴露在相同的 HD 暴露环境中。
在停止使用 HD 后，成人慢性 HDLI 表现以小叶中心结节为主（95.2%），而在儿童中，胸部 CT 最常见的表现为正常模式（45.5%），其次是小叶中心结节（36.4%）、奇异肺囊肿（36.4%）和网状影（13.6%）。
与成人已知的慢性 HDLI 表现不同，儿童中仅 36.4%存在小叶中心结节。停止类似 HD 暴露后，儿童奇异肺囊肿的发生率明显高于成人。因此，奇异肺囊肿可能是儿童慢性 HDLI 的另一种新表现，这些儿童没有肺部感染或其他围产期疾病史，如透明膜病或其他间质性肺病。
