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氧化锌纳米粒子（ZnO NPs）与顺铂和吉西他滨联合抑制非小细胞肺癌细胞的肿瘤活性。

Zinc oxide nanoparticles (ZnO NPs) combined with cisplatin and gemcitabine inhibits tumor activity of NSCLC cells.

机构信息

Scientific Research Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

Respiratory Ward One, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

出版信息

Aging (Albany NY). 2020 Nov 20;12(24):25767-25777. doi: 10.18632/aging.104187.

DOI:10.18632/aging.104187
PMID:33232271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7803530/
Abstract

Non-small cell lung cancer (NSCLC) is one of the most common malignancies worldwide. The use of a combination of chemotherapy drugs and zinc oxide nanoparticles (ZnO-NPs), which have proven to induce tumor-selective cell death, reduce the drug resistance and reduce the side effects . In the present study, we developed ZnO-NPs loaded with both cisplatin (Cp) and gemcitabine (Gem) (ZnO-NPs(Cp/Gem)), then the morphologies and the size distribution of ZnO-NPs(Cp/Gem) particles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Also, MTT, western blot and Annexin V-PI were used to assess the anti-tumor role of ZnO-NPs(Cp/Gem) in A549 cells. The viability for A549 cells showed a significant decrease in the ZnO NPs(Cp/Gem) group, respectively relative to Cp, Gem, the combination of Cp and Gem (Cp+Gem), and ZnO-NPs loaded with Cp (ZnO-NPs(Cp)) or Gem (ZnO-NPs(Gem)). Furthermore, ZnO-NPs(Cp/Gem) remarkably enhanced the apoptosis-promoting effect of Cp and Gem in A549 cells. The xenograft model showed that Zno-NPS (Cp/Gem) significantly enhanced the inhibition of Cp and Gem on tumor formation. The above results suggested that therapy of NSCLC with ZnO-NPs(Cp/Gem) could enhance the cytotoxic action of chemotherapeutic agents synergistically, indicating a promising potential for ZnO-NPs in antitumor applications.

摘要

非小细胞肺癌（NSCLC）是世界上最常见的恶性肿瘤之一。联合使用化疗药物和氧化锌纳米粒子（ZnO-NPs）已被证明能诱导肿瘤选择性细胞死亡，降低耐药性并减少副作用。在本研究中，我们开发了负载顺铂（Cp）和吉西他滨（Gem）的 ZnO-NPs（ZnO-NPs（Cp/Gem）），然后通过透射电子显微镜（TEM）和动态光散射（DLS）观察 ZnO-NPs（Cp/Gem）颗粒的形态和粒径分布。此外，还使用 MTT、western blot 和 Annexin V-PI 来评估 ZnO-NPs（Cp/Gem）在 A549 细胞中的抗肿瘤作用。与 Cp、Gem、Cp 和 Gem 的联合（Cp+Gem）以及负载 Cp 的 ZnO-NPs（ZnO-NPs（Cp））或 Gem 的 ZnO-NPs（ZnO-NPs（Gem））相比，A549 细胞的活力显著下降。此外，ZnO-NPs（Cp/Gem）显著增强了 Cp 和 Gem 在 A549 细胞中的促凋亡作用。异种移植模型表明，Zno-NPS（Cp/Gem）显著增强了 Cp 和 Gem 对肿瘤形成的抑制作用。上述结果表明，用 ZnO-NPs（Cp/Gem）治疗 NSCLC 可以协同增强化疗药物的细胞毒性作用，表明 ZnO-NPs 在抗肿瘤应用中具有很大的应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/92efd4733dcb/aging-12-104187-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/aab0ccfa10ef/aging-12-104187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/2524ca021394/aging-12-104187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/12543e8932b7/aging-12-104187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/b19967d36eb1/aging-12-104187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/5f5f9d4a3b2a/aging-12-104187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/b6e8ecd55616/aging-12-104187-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/92efd4733dcb/aging-12-104187-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/aab0ccfa10ef/aging-12-104187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/2524ca021394/aging-12-104187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/12543e8932b7/aging-12-104187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/b19967d36eb1/aging-12-104187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/5f5f9d4a3b2a/aging-12-104187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/b6e8ecd55616/aging-12-104187-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/7803530/92efd4733dcb/aging-12-104187-g007.jpg

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