酒精使用障碍伴或不伴共病物质使用障碍患者的焦虑、抑郁和边缘型人格障碍症状。
Symptoms of anxiety, depression, and borderline personality in alcohol use disorder with and without comorbid substance use disorder.
机构信息
Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, 47405, United States.
Department of Psychology, University of Kentucky, Lexington, KY, 40506, United States.
出版信息
Alcohol. 2021 Feb;90:19-25. doi: 10.1016/j.alcohol.2020.11.002. Epub 2020 Nov 21.
OBJECTIVE
Alcohol use disorder (AUD) is highly comorbid with other substance use disorders (SUDs) as well as other psychiatric disorders, such as anxiety, depression, and Borderline Personality Disorder (BPD). However, studies of persons with AUD rarely account for its comorbidity with other SUDs. Some research suggests that BPD symptoms reflect an important connection between internalizing disorders and SUDs. The current study investigated: 1) the levels of trait anxiety and symptoms of depression and BPD in persons with an AUD as a function of comorbid SUDs (cannabis use disorder - CUD) and other substance use disorder (oSUD), and 2) the influence of BPD on the association between severity of overall lifetime SUD symptoms (AUD + CUD + oSUD) and both trait anxiety and symptoms of depression.
METHOD
Trait anxiety and symptoms of depression and BPD were assessed in 671 young adults (351 men; 320 women; mean age 21 years) separated into four groups: Controls (n = 185), AUD-only (134), AUD + CUD (n = 210), and AUD + oSUD (n = 142).
RESULTS
Trait anxiety and symptoms of depression and BPD were elevated in all AUD groups compared with controls, and in the AUD + oSUD group compared with all other groups as well. Structural models also indicated that BPD symptoms accounted for all of the variance in lifetime SUD symptoms associated with Trait Anxiety, and a significant portion of the variance in lifetime SUD symptoms associated with depression symptoms.
CONCLUSION
Results indicate that when AUD is comorbid with oSUD, it is associated with more severe AUD symptoms and higher levels of trait anxiety and symptoms of both depression and BPD. The results also indicate that BPD symptoms account for the majority of the variance in SUD symptoms associated with both trait anxiety and depression, suggesting that a considerable amount of the internalizing symptomatology in AUD/SUDs is associated with BPD psychopathology.
目的
酒精使用障碍（AUD）与其他物质使用障碍（SUD）以及其他精神障碍高度共病，如焦虑、抑郁和边缘型人格障碍（BPD）。然而，研究 AUD 的人员很少考虑到其与其他 SUD 的共病。一些研究表明，BPD 症状反映了内化障碍和 SUD 之间的重要联系。本研究调查了：1）共病 SUD（大麻使用障碍-CUD）和其他物质使用障碍（o-SUD）的 AUD 患者的特质焦虑和抑郁及 BPD 症状的水平，以及 2）BPD 对整体终生 SUD 症状（AUD+CUD+o-SUD）与特质焦虑和抑郁症状之间关联的影响。
方法
在 671 名年轻成年人（351 名男性；320 名女性；平均年龄 21 岁）中评估了特质焦虑和抑郁及 BPD 症状，分为四组：对照组（n=185）、AUD 仅（n=134）、AUD+CUD（n=210）和 AUD+o-SUD（n=142）。
结果
与对照组相比，所有 AUD 组的特质焦虑和抑郁及 BPD 症状均升高，且 AUD+o-SUD 组与所有其他组相比也是如此。结构模型还表明，BPD 症状解释了与特质焦虑相关的终生 SUD 症状的所有差异，以及与抑郁症状相关的终生 SUD 症状的显著部分差异。
结论
结果表明，当 AUD 与 o-SUD 共病时，它与更严重的 AUD 症状以及更高的特质焦虑和抑郁及 BPD 症状相关。结果还表明，BPD 症状解释了与特质焦虑和抑郁相关的 SUD 症状的大部分差异，这表明 AUD/SUD 中的大量内化症状与 BPD 病理生理学有关。
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