Carpenter Ryan W, Wood Phillip K, Trull Timothy J
University of Missouri-Columbia.
J Pers Disord. 2016 Jun;30(3):336-50. doi: 10.1521/pedi_2015_29_197. Epub 2015 Apr 20.
Borderline personality disorder (BPD) is comorbid with substance use disorders (SUDs). However, most epidemiological work on BPD and SUDs has collapsed nonalcohol substances into a drug use disorder indicator, potentially obscuring patterns of association between BPD and individal SUDs. Using a nationally representative sample (National Epidemiologic Survey on Alcohol and Related Conditions; N = 34,481), the authors examined the association between lifetime BPD and nine lifetime SUDs. First, the authors examined the bivariate association of BPD and each SUD. BPD was associated with all nine SUDs. Second, they added relevant covariates (demographic variables, additional psychopathology) to each model. Seven SUDs remained significant. Finally, to account for shared variance across SUDs, the authors conducted a multivariate logistic regression with the nine SUDs and covariates as predictors. Alcohol, cocaine, and opiate use disorder were the only significant SUD predictors, indicating a unique association between BPD and these three SUDs. Future research should explore factors involved in the association of BPD with these specific SUDs.
边缘型人格障碍（BPD）与物质使用障碍（SUDs）共病。然而，大多数关于BPD和SUDs的流行病学研究都将非酒精类物质纳入药物使用障碍指标中，这可能会掩盖BPD与个体SUDs之间的关联模式。作者使用全国代表性样本（全国酒精及相关状况流行病学调查；N = 34,481），研究了终生BPD与九种终生SUDs之间的关联。首先，作者研究了BPD与每种SUD的双变量关联。BPD与所有九种SUDs相关。其次，他们在每个模型中加入了相关协变量（人口统计学变量、其他精神病理学因素）。七种SUDs仍然显著。最后，为了考虑SUDs之间的共同方差，作者进行了多变量逻辑回归，将九种SUDs和协变量作为预测因子。酒精、可卡因和阿片类药物使用障碍是仅有的显著SUD预测因子，表明BPD与这三种SUDs之间存在独特关联。未来的研究应探索BPD与这些特定SUDs关联中涉及的因素。
