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放射性药物化学共识命名规则 - 放射性化学转化的再思考。

On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion.

机构信息

Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.

出版信息

Nucl Med Biol. 2021 Feb;93:19-21. doi: 10.1016/j.nucmedbio.2020.11.003. Epub 2020 Nov 18.

Abstract

Radiochemical conversion is an important term to be included in the "Consensus nomenclature rules for radiopharmaceutical chemistry". Radiochemical conversion should be used to define reaction efficiency by measuring the transformation of components in a crude reaction mixture at a given time, whereas radiochemical yield is better suited to define the efficiency of an entire reaction process including, for example, separation, isolation, filtration, and formulation.

摘要

放射化学转化率是“放射性药物化学共识命名规则”中需要包含的一个重要术语。放射化学转化率应该用于通过测量给定时间内粗反应混合物中成分的转化来定义反应效率,而放射化学产率则更适合于定义整个反应过程的效率,例如分离、分离、过滤和配方。

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