源自体外受精胚胎和孤雌生殖胚胎的多能猪胚胎干细胞系。
Pluripotent pig embryonic stem cell lines originating from in vitro-fertilized and parthenogenetic embryos.
作者信息
Choi Kwang-Hwan, Lee Dong-Kyung, Oh Jong-Nam, Kim Seung-Hun, Lee Mingyun, Woo Sang-Ho, Kim Dae-Yong, Lee Chang-Kyu
机构信息
Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Republic of Korea.
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea.
出版信息
Stem Cell Res. 2020 Dec;49:102093. doi: 10.1016/j.scr.2020.102093. Epub 2020 Nov 19.
Here, we report in vivo developmental competent pig embryonic stem cells (ESCs) originating from in vitro-fertilized and parthenogenetic embryos cultured in chemically defined culture media. The pig ESC lines expressed pluripotency markers and were capable of forming teratomas following subcutaneous injection into nude mice. These cell lines would be a useful resource for comparative developmental biology and agricultural biotechnology.
在此，我们报告了源自体外受精胚胎和孤雌生殖胚胎、在化学成分明确的培养基中培养的具有体内发育能力的猪胚胎干细胞（ESC）。这些猪胚胎干细胞系表达多能性标志物，皮下注射到裸鼠体内后能够形成畸胎瘤。这些细胞系将为比较发育生物学和农业生物技术提供有用的资源。
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