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在高脂饮食诱导的肥胖模型中，桑色素和多不饱和脂肪酸对Nlrp3炎性小体mRNA的调节作用。

Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet.

作者信息

López-Tenorio Itzel Ivonn, Domínguez-López Aarón, Miliar-García Ángel, Escalona-Cardoso Gerardo Norberto, Real-Sandoval Samantha Alejandra, Gómez-Alcalá Alejandro, Jaramillo-Flores María Eugenia

机构信息

Laboratorio de Nutrigenómica de alimentos funcionales y nutracéuticos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Av. Wilfrido Massieu Esq. Cda. Manuel Stampa S/N Col. Unidad Profesional López Mateos, Alcaldía Gustavo A. Madero C.P. 07738 CDMX, Mexico.

Laboratorio de Biología Molecular, Escuela Superior de Medicina, Instituto Politécnico Nacional (IPN), Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Delegación Miguel Hidalgo, C.P. 11340 CDMX, Mexico.

出版信息

Food Res Int. 2020 Nov;137:109706. doi: 10.1016/j.foodres.2020.109706. Epub 2020 Sep 18.

DOI:10.1016/j.foodres.2020.109706
PMID:33233280
Abstract

Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.

摘要

桑色素和多不饱和脂肪酸（PUFAs）是饮食中含有的生物活性化合物，具有多种生物学活性，其中包括对各种慢性疾病炎症的调节作用。在通过高脂饮食建立的肥胖模型中，评估了连续8周给予桑色素、PUFAs以及两者混合物对Nlrp3炎性小体的mRNA表达水平以及与炎症和脂质代谢相关基因的影响。三种处理均对Nlrp3 mRNA的表达产生负调控作用。桑色素除了对过氧化物酶体增殖物激活受体α（Ppar-α）以及脂联素的mRNA表达产生正向调节作用外，还通过下调白细胞介素-18（Il-18）、半胱天冬酶-1（Casp-1）、过氧化物酶体增殖物激活受体γ（Pparγ）和丝氨酸/苏氨酸蛋白磷酸酶-1c（Serbp-1c）的mRNA表达，表现出更好的效果。桑色素与PUFAs的联合处理使Toll样受体4（Tlr4）和解偶联蛋白2（Ucp2）的mRNA表达在正常条件下保持相似水平。

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