Khademi Reza, Mirzaei Ali, Mirzaei Amirhossein, Edjlali Farid Reza, Askari Vahid Reza, Baradaran Rahimi Vafa
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 14. doi: 10.1007/s00210-024-03783-4.
The present investigation evaluated the potential impacts of morin, a natural flavonoid, against cardiovascular disorders. Since inception until September 2024, PubMed, Scopus, and Web of Science have been searched extensively. The process involved eliminating duplicate entries and conducting a systematic review of the remaining studies post-full-text screening. The search was conducted with meticulousness and in adherence to established protocols. Morin has shown various cardioprotective effects in experimental models. It reduces oxidative stress, inflammation, and tissue damage in conditions like myocardial ischemia, injury, and infarction. It also mitigates the harmful effects of toxins and improves hemodynamic parameters, antioxidant levels, and cardiac function. Moreover, it can address conditions like chronic iron overload and metabolic syndrome. Its mechanisms of action involve regulating signaling pathways, promoting autophagy, and reducing oxidative stress and inflammation. Morin hydrate is promising as a therapeutic agent for cardiovascular and related disorders. Morin Hydrate exhibits promising cardioprotective properties, effectively reducing oxidative stress and inflammation in myocardial conditions while also countering the effects of toxins and improving heart function. Additionally, it holds the potential for addressing chronic iron overload and metabolic syndrome. Its multifaceted mechanisms, including signaling pathway regulation and promotion of autophagy, highlight its therapeutic potential for various cardiovascular and related disorders.
本研究评估了天然黄酮类化合物桑色素对心血管疾病的潜在影响。自开始至2024年9月，对PubMed、Scopus和Web of Science进行了广泛检索。该过程包括消除重复条目，并在全文筛选后对其余研究进行系统综述。检索工作严谨且遵循既定方案。桑色素在实验模型中显示出多种心脏保护作用。它可减轻心肌缺血、损伤和梗死等情况下的氧化应激、炎症和组织损伤。它还能减轻毒素的有害影响，改善血流动力学参数、抗氧化水平和心脏功能。此外，它可应对慢性铁过载和代谢综合征等情况。其作用机制包括调节信号通路、促进自噬以及减轻氧化应激和炎症。水合桑色素有望成为治疗心血管及相关疾病的药物。水合桑色素具有良好的心脏保护特性，能有效减轻心肌疾病中的氧化应激和炎症，同时还能对抗毒素的影响并改善心脏功能。此外，它有解决慢性铁过载和代谢综合征的潜力。其多方面的机制，包括信号通路调节和自噬促进，凸显了其对各种心血管及相关疾病的治疗潜力。
