Department of Pathology, Wayne State University, Detroit, MI 48201, USA.
Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Genes (Basel). 2020 Nov 20;11(11):1372. doi: 10.3390/genes11111372.
Cancer stem cells (CSCs) are a class of pluripotent cells that have been observed in most types of cancers. Evolving evidence suggests that CSCs, has the ability to self-renew and initiate tumors, may be responsible for promoting therapeutic resistance, tumor recurrence and metastasis. Tumor heterogeneity is originating from CSCs and its progenitors are recognized as major difficulty in efficaciously treating cancer patients. Therefore, understanding the biological mechanisms by which CSCs survive chemo- and-radiation therapy has the potential to identify new therapeutic strategies in the future. In this review, we summarized recent advances in CSC biology and their environment, and discuss about the potential therapies to prevent therapeutic resistance.
癌症干细胞（CSCs）是一类多能细胞，已在大多数类型的癌症中观察到。不断发展的证据表明，CSCs 具有自我更新和引发肿瘤的能力，可能是导致治疗耐药、肿瘤复发和转移的主要原因。肿瘤异质性源自 CSCs，其祖细胞被认为是有效治疗癌症患者的主要困难。因此，了解 CSCs 如何在化疗和放疗中存活的生物学机制有可能为未来确定新的治疗策略。在这篇综述中，我们总结了 CSC 生物学及其微环境的最新进展，并讨论了预防治疗耐药性的潜在治疗方法。
