二人为舞：免疫与干细胞在健康与疾病中的对话。
Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease.
机构信息
Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
出版信息
Cell. 2018 Nov 1;175(4):908-920. doi: 10.1016/j.cell.2018.08.071.
Abstract
Stem cells regenerate tissues in homeostasis and under stress. By taking cues from their microenvironment or "niche," they smoothly transition between these states. Immune cells have surfaced as prominent members of stem cell niches across the body. Here, we draw parallels between different stem cell niches to explore the context-specific interactions that stem cells have with tissue-resident and recruited immune cells. We also highlight stem cells' innate ability to sense and respond to stress and the enduring memory that forms from such encounters. This fascinating crosstalk holds great promise for novel therapies in inflammatory diseases and regenerative medicine.
摘要
干细胞在体内平衡和应激状态下再生组织。通过从其微环境或“生态位”中获取线索，它们可以在这些状态之间顺利转换。免疫细胞已经成为全身干细胞生态位中突出的成员。在这里，我们将不同的干细胞生态位进行对比，以探讨干细胞与组织驻留和募集的免疫细胞之间的特定于环境的相互作用。我们还强调了干细胞感知和应对应激的固有能力，以及由此产生的持久记忆。这种引人入胜的串扰为炎症性疾病和再生医学的新疗法带来了巨大的希望。
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